{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:05:45Z","timestamp":1777878345239,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200223, 82370205, 82070223"],"award-info":[{"award-number":["82200223, 82370205, 82070223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Social Development Project of Jiangsu Science and Technology Plan","award":["BK20220718"],"award-info":[{"award-number":["BK20220718"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Solitary plasmacytoma (SP) is a rare plasmacytoma. Research on clinical characteristics and prognostic factors for SP is very limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the clinical attributes and prognostic indicators for individuals afflicted with SP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>We retrospectively analyzed the clinical parameters and survival data of 49 patients diagnosed with SP from three centers between the year 2009 and 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The Kaplan-Meier curves were constructed to compare the survival outcomes. The independent risk factors were determined based on the Cox proportional hazards model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among the 49 patients with SP, 30 (61.2%) were classified as solitary bone plasmacytoma (SBP), while 19 (38.8%) had solitary extramedullary plasmacytoma (SEP). Anatomically, SEPs predominantly localized to the upper aerodigestive tract (47.4%), whereas SBPs exhibited a predilection for the axial spine (30.0%) and appendicular long bones (20.0%). Survival analysis revealed significantly reduced progression-free survival (PFS) in the SBP cohort compared to SEP patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002), though no statistically significant difference in overall survival was observed between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.1012). Radiotherapy in conjunction with surgery or chemotherapy did not substantially enhance the outcome of the patients with SP. Multivariate Cox regression analysis identified SBP subtype (hazard ratio (HR)\u2009=\u20090.068, 95% confidence interval (CI): 0.008\u20130.537,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and elevated Ki67 expression (HR\u2009=\u20094.545, 95% CI: 1.005\u201320.542,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049) as independent prognostic factors for inferior PFS. Notably, SBP patients with Ki67 expression exceeding 35% demonstrated the poorest clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The prognosis of patients with SBP was poorer than that with SEP. Patients with SBP exhibiting Ki67 expression exceeding 35% had the poorest outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20406207251379690","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:43:55Z","timestamp":1759999435000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics and prognostic factors of patients with solitary plasmacytoma: a multicenter retrospective study"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-1463","authenticated-orcid":false,"given":"Xuxing","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenmin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7677-7738","authenticated-orcid":false,"given":"Yuanyuan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuzhang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuezhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6497-1194","authenticated-orcid":false,"given":"Lijuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023021859"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-566521"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.166"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.01.004"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-019-00499-8"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030676"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.05.009"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0549-1"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26590"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-002-0015-2"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-567909"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10366"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2910"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1052903"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3533"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813481334"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12907"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-118"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)01572-8"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.06.039"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.282214"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024013355"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-015784"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14291"},{"issue":"7","key":"e_1_3_4_27_2","first-page":"2210","article-title":"Bone 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