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Radiotherapy combined with immune checkpoint inhibitors (ICIs) may exert synergistic effects, including local tumor control through radiation-induced DNA damage and systemic immune activation via modulation of the tumor immune microenvironment. This case report describes a patient with relapsed\/refractory (R\/R) B-cell lymphoma who experienced multiple relapses and treatment failures, including CD19 CAR-T therapy. Almost 7 years after CAR-T treatment, the patient developed disease relapse and was diagnosed with follicular lymphoma (FL). The patient received a personalized treatment strategy combining hypo-fractionated radiotherapy (30 Gy\/5 fractions) and the Programmed Death-1 (PD-1) inhibitor camrelizumab, achieving complete remission (CR) and remaining disease-free for over 43 months. This case highlights the potential efficacy of this combination strategy in R\/R lymphoma, particularly in patients with limited treatment options.<\/jats:p>","DOI":"10.1177\/20406207261478443","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:20:37Z","timestamp":1786738837000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypo-fractionated radiotherapy combined with PD-1 inhibitor for relapsed\/refractory B-cell lymphoma after failure to CD19 CAR-T therapy"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3372-0723","authenticated-orcid":false,"given":"Min","family":"Li","sequence":"first","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Qinhuangdao Hospital"},{"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Bao","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Peng","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Jing","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2027612"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.131"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-769620"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2115304"},{"issue":"19","key":"e_1_3_8_6_2","first-page":"2307","article-title":"Five-year follow-up of ZUMA-1 supports the curative potential of axicabtagene ciloleucel in refractory large B-cell lymphoma","volume":"141","author":"Neelapu SS","year":"2023","unstructured":"Neelapu SS, Jacobson CA, Ghobadi A, et al. 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