{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:25:44Z","timestamp":1787315144062,"version":"build-2736575974"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Acute myeloid leukemia (AML) is a hematologic malignancy caused by the malignant proliferation and differentiation block of immature myeloid cells (blasts) in the bone marrow. The pathogenesis, diagnostic classification, treatment, and prognosis of AML are fundamentally linked to the accumulation of genetic variants, fusion gene formation, and chromosomal karyotype abnormalities. Using mRNA sequencing (next-generation sequencing, NGS), we identified and validated two novel fusion genes,\n                    <jats:italic toggle=\"yes\">UBE2E3::PDE1A<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">CTC1::MEF2C<\/jats:italic>\n                    , in a case of AML-M2a. This patient also harbored six single nucleotide variants (SNV) (\n                    <jats:italic toggle=\"yes\">EP300<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">KRAS<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">NRAS<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">RAD21<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">TET2<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    ) and complex karyotype (CK). The chromosomes exhibited extreme instability and high variability, with tumor cells containing multiple clones and showing continuous karyotype evolution as the disease progressed. The patient was treated with three chemotherapy regimens (VMA, VHAA, and Decitabine-Venetoclax), but none achieved remission. We propose that the combination of these novel fusion genes, multiple SNVs, and the complex karyotype collectively contributed to the patient\u2019s multidrug resistance.\n                  <\/jats:p>","DOI":"10.1177\/20406207261480375","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:10:25Z","timestamp":1787076625000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of novel\n                    <i>UBE2E3::PDE1A<\/i>\n                    and\n                    <i>CTC1::MEF2C<\/i>\n                    fusion transcripts in acute myeloid leukemia"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8155-3794","authenticated-orcid":false,"given":"Jifang","family":"Tu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine"},{"name":"Department of Hematology, Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yungui","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine"},{"name":"Department of Hematology, Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangli","family":"Gao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanping","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine"},{"name":"Department of Hematology, Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine"},{"name":"Department of Hematology, Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Jin","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine"},{"name":"Department of Hematology, Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies"},{"name":"Department of Hematology, Zhejiang Provincial Clinical Research Center for Hematological Disorders"},{"name":"Department of Hematology, Zhejiang University Cancer Center"},{"name":"Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-4160","authenticated-orcid":false,"given":"Hongyan","family":"Tong","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine"},{"name":"Department of Hematology, Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies"},{"name":"Department of Hematology, Zhejiang Provincial Clinical Research Center for Hematological Disorders"},{"name":"Department of Hematology, Zhejiang University Cancer Center"},{"name":"Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406184"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516192"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-020-00674-7"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-343988"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000015229"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(00)00293-1"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01262-x"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051368"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8986"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky114"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adt3034"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22899"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-158196"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116343"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-015-0215-4"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2190432"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2864-x"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-01940-5"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-024-01771-2"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01186-5"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004259"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44239-2"}],"container-title":["Therapeutic Advances in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20406207261480375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20406207261480375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20406207261480375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:49:21Z","timestamp":1787312961000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20406207261480375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":22,"alternative-id":["10.1177\/20406207261480375"],"URL":"https:\/\/doi.org\/10.1177\/20406207261480375","relation":{},"ISSN":["2040-6207","2040-6215"],"issn-type":[{"value":"2040-6207","type":"print"},{"value":"2040-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"20406207261480375"}}