{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:17:12Z","timestamp":1787926632689,"version":"build-2784847793"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["ZR2024QH639"],"award-info":[{"award-number":["ZR2024QH639"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Youth Research Foundation of Affiliated Hospital of Qingdao University","award":["QDFYQN2023212"],"award-info":[{"award-number":["QDFYQN2023212"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Relapsed and refractory multiple myeloma (RRMM) is generally associated with a poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This real-world study aims to evaluate the efficacy and safety of the carfilzomib\u2013pomalidomide\u2013dexamethasone (KPd) regimen in patients with RRMM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A multicenter, retrospective study was conducted in four centers in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>RRMM patients who received at least 1 cycle of KPd across four centers were retrospectively included and stratified by prior lines of treatment, survival outcomes and safety profile were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 82 patients were enrolled. Based on the lines of treatment (LOT) at KPd initiation, patients were stratified into second-line (2L, n=39), third-line (3L, n=26), and fourth-line or beyond (4L+, n=17) groups. Among 72 response-evaluable patients, the overall response rate (ORR) was 69.4%, with ORRs of 79.4%, 73.9%, and 40.0% in the 2L, 3L, and 4L+ groups, respectively. After a median follow-up of 10.8 months, the median progression-free survival (mPFS) for the entire cohort was 22.5 months, while the median overall survival (mOS) was not reached (NR). The mPFS was NR, 22.5, and 10.1 months (P=0.178), and the mOS was NR, NR, and 11.6 months (P=0.019) for patients receiving KPd in the 2L, 3L, and 4L+ settings, respectively. Multivariable analysis identified elevated lactate dehydrogenase (LDH) level (HR=3.489, 95% CI: 1.557\u20137.823) and LOT \u22654 (HR=2.791, 95% CI: 1.086\u20137.177) as independent predictors of inferior PFS (P&lt;0.05), while LOT \u22654 (HR=3.917, 95% CI: 1.258\u201312.200) was also associated with worse OS (P=0.019). Grade \u22653 adverse events (AEs) occurred in 12.8%, 50.0%, and 47.1% of patients in the 2L, 3L, and 4L+ groups, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The KPd regimen demonstrated favorable clinical efficacy and manageable toxicity in RRMM, particularly in those with early-line relapse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20406207261481202","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T19:37:56Z","timestamp":1787686676000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-world efficacy and safety of the carfilzomib\u2013pomalidomide\u2013dexamethasone regimen in patients with relapsed\/refractory multiple myeloma: A multicenter retrospective study"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9924-4811","authenticated-orcid":false,"given":"Huishou","family":"Fan","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Qingdao University, Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiangYan","family":"Feng","sequence":"additional","affiliation":[{"name":"Yantai Yuhuangding Hospital Affiliated to Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxia","family":"Wei","sequence":"additional","affiliation":[{"name":"Yantai Yuhuangding Hospital Affiliated to Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Weifang People\u2019s 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