{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:43:59Z","timestamp":1787330639917,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500213"],"award-info":[{"award-number":["82500213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"crossref","award":["JCYJ20250604141706008"],"award-info":[{"award-number":["JCYJ20250604141706008"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Blood Center Scientific Research Project Fund","award":["SZBC202403"],"award-info":[{"award-number":["SZBC202403"]}]},{"name":"Sanming Project of Medicine in Shenzen","award":["SZSM202311032"],"award-info":[{"award-number":["SZSM202311032"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Hematology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Ewing sarcoma breakpoint region 1 (\n                    <jats:italic toggle=\"yes\">EWSR1<\/jats:italic>\n                    ):: Fifth Ewing variant (\n                    <jats:italic toggle=\"yes\">FEV<\/jats:italic>\n                    )-positive acute leukemia is exceptionally rare, and its clinicopathological features, molecular profile, and optimal treatment remain poorly defined. Here, we report a case of acute myeloid leukemia (AML) with bone marrow hypocellularity, aberrant lymphoid antigen expression, and an\n                    <jats:italic toggle=\"yes\">EWSR1::FEV<\/jats:italic>\n                    fusion. A 45-year-old man was admitted with a 1-month history of petechiae and fatigue. Complete blood count (CBC) showed pancytopenia. Bone marrow (BM) examination revealed hypocellular marrow, with blasts accounting for 62% of nucleated cells. Flow cytometry (FCM) revealed a predominantly myeloid immunophenotype accompanied by aberrant expression of lymphoid-associated antigens. Conventional karyotyping did not identify a characteristic balanced translocation. Targeted next-generation sequencing (NGS) detected concurrent\n                    <jats:italic toggle=\"yes\">PTPN11<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">NRAS<\/jats:italic>\n                    mutations. RNA sequencing (RNA-seq) of the bone marrow sample identified the\n                    <jats:italic toggle=\"yes\">EWSR1::FEV<\/jats:italic>\n                    fusion. Based on these findings, the patient was diagnosed with de novo AML with bone marrow hypocellularity and aberrant lymphoid antigen expression. Given the hypocellular marrow, venetoclax plus azacitidine (VA) was selected as induction therapy. The patient achieved morphological complete remission after one cycle, accompanied by a marked reduction in\n                    <jats:italic toggle=\"yes\">EWSR1::FEV<\/jats:italic>\n                    transcript levels, and remained in morphological remission during approximately 6 months of follow-up after subsequent homoharringtonine combined with venetoclax plus azacitidine (HVA) consolidation. Together with previously reported cases, this case further supports the notion that\n                    <jats:italic toggle=\"yes\">EWSR1::FEV<\/jats:italic>\n                    -positive acute leukemia may represent a distinct molecular subset characterized by lineage ambiguity, fusion-driven biology, and potentially unique therapeutic vulnerabilities. This case also suggests potential activity of venetoclax-based therapy in\n                    <jats:italic toggle=\"yes\">EWSR1::FEV<\/jats:italic>\n                    -positive leukemia and warrants further investigation in additional cases.\n                  <\/jats:p>","DOI":"10.1177\/20406207261481219","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:47:06Z","timestamp":1787168826000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypoplastic acute myeloid leukemia with aberrant lymphoid antigen expression and\n                    <i>EWSR1::FEV<\/i>\n                    fusion: A rare case report and literature review"],"prefix":"10.1177","volume":"17","author":[{"given":"Wenxia","family":"Xia","sequence":"first","affiliation":[{"name":"Shenzhen Blood Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Zou","sequence":"additional","affiliation":[{"name":"Tianjin Union Precision Diagnosis Co., Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Feng","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Dai","sequence":"additional","affiliation":[{"name":"Wuhan Kanglu Biomedical Co., Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Ding","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-192X","authenticated-orcid":false,"given":"Jihao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Ke","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7057-7616","authenticated-orcid":false,"given":"Huijun","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3463-7271","authenticated-orcid":false,"given":"Junjie","family":"Hou","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201845766"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060614-034325"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11061093"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(02)01156-3"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.188872"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjp025"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/35099076"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.036"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22828"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2028910"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2025.105960"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001934"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2022.151942"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201554"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.03.003"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes14061139"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-02102-9"},{"key":"e_1_3_8_21_2","article-title":"Detection of fusion genes using RNA sequencing in acute leukemia","author":"Kim HY","year":"2025","unstructured":"Kim HY, Kim B, Park MS, et al. 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