{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:20:14Z","timestamp":1788358814827,"version":"build-2803163510"},"reference-count":7,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Chronic Disease"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of the study was to evaluate the prevalence of and illness characteristics in adults with major depressive disorder (MDD) with anxious distress specifier (ADS) enrolled in the International Mood Disorders Collaborative Project, which is a collaborative research platform at the Mood Disorders Psychopharmacology Unit, University of Toronto, Canada and the Cleveland Clinic, Cleveland, Ohio, USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data from participants who met criteria for a current major depressive episode as part of MDD ( n = 830) were included in this post hoc analysis. Diagnostic and Statistical Manual Version-5-defined ADS was operationalized as the presence of at least two out of three proxy items instead of two out of five specifiers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 464 individuals (i.e. 56%) met criteria for ADS. There were no between-group differences in sociodemographic variables (e.g. gender, employment, marital status). Greater severity of illness was observed in adults with ADS as evidenced by a higher number of hospitalizations, higher rates of suicidal ideation, greater depressive symptom severity, greater workplace impairment, decreased quality of life, and greater self-reported cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings underscore the importance of evaluating ADS in adults with MDD as its presence identifies a subpopulation with greater illness-associated burden and hazards.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2040622315627805","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T21:43:39Z","timestamp":1454363019000},"page":"153-159","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":56,"title":["The prevalence and clinical characteristics associated with Diagnostic and Statistical Manual Version-5-defined anxious distress specifier in adults with major depressive disorder: results from the International Mood Disorders Collaborative Project"],"prefix":"10.1177","volume":"7","author":[{"given":"Roger S.","family":"McIntyre","sequence":"first","affiliation":[{"name":"Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna O.","family":"Woldeyohannes","sequence":"additional","affiliation":[{"name":"Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna K.","family":"Soczynska","sequence":"additional","affiliation":[{"name":"Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada, and Institute of Medical Science, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maj","family":"Vinberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychiatric Center, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle S.","family":"Cha","sequence":"additional","affiliation":[{"name":"Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada, and Institute of Medical Science, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yena","family":"Lee","sequence":"additional","affiliation":[{"name":"Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Gallaugher","sequence":"additional","affiliation":[{"name":"Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman S.","family":"Dale","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad T.","family":"Alsuwaidan","sequence":"additional","affiliation":[{"name":"Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo B.","family":"Mansur","sequence":"additional","affiliation":[{"name":"Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Muzina","sequence":"additional","affiliation":[{"name":"Medco Health Solutions, Inc., Fort Worth, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Research Group and Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada, and Institute of Medical Science, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"bibr1-2040622315627805","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2014.969689"},{"key":"bibr2-2040622315627805","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291704002612"},{"key":"bibr3-2040622315627805","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.06111868"},{"key":"bibr4-2040622315627805","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb05800.x"},{"key":"bibr5-2040622315627805","doi-asserted-by":"publisher","DOI":"10.1002\/da.22063"},{"key":"bibr6-2040622315627805","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2014.08.051"},{"key":"bibr7-2040622315627805","first-page":"6","volume":"24","author":"Schaffer A.","year":"2012","journal-title":"Ann Clin Psychiatry"}],"container-title":["Therapeutic Advances in Chronic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2040622315627805","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2040622315627805","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2040622315627805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:17:21Z","timestamp":1777591041000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2040622315627805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,1]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1177\/2040622315627805"],"URL":"https:\/\/doi.org\/10.1177\/2040622315627805","relation":{},"ISSN":["2040-6223","2040-6231"],"issn-type":[{"value":"2040-6223","type":"print"},{"value":"2040-6231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,1]]}}}