{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:14:04Z","timestamp":1790072044393,"version":"4.0.1"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007772","name":"Agir pour les Maladies Chroniques","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-IDEX-02"],"award-info":[{"award-number":["ANR-15-IDEX-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Chronic Disease"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Chronic intermittent hypoxia (IH), the hallmark feature of obstructive sleep apnoea syndrome, contributes to infarct size enhancement after myocardial ischemia\u2013reperfusion (I\/R). Curcumin (Curc), the natural pigment of Curcuma longa, has been demonstrated to be beneficial in the context of myocardial injury. In this study, we assessed the effects of Curc on the maladaptive cardiac response to IH, and particularly on IH-induced hypoxia inducible factor-1 (HIF-1) expression, oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Swiss\/SV129 mice were exposed to normoxia or IH (21\u20135% FiO\n                      <jats:sub>2<\/jats:sub>\n                      , 60\u2009s cycles, 8\u2009h per day, for 21\u2009days) and treated orally with Curc (100\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      day\n                      <jats:sup>\u22121<\/jats:sup>\n                      , oral gavage) or its vehicle. Mice were then either euthanised for heart sampling in order to perform biochemical and histological analysis, or subjected to an in vivo ischemia-reperfusion protocol in order to measure infarct size.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      IH increased nuclear HIF-1\u03b1 expression and superoxide anion (O\n                      <jats:sub>2<\/jats:sub>\n                      <jats:sup>.\u2013<\/jats:sup>\n                      ) production as well as nuclear factor kappa B (NF-kB) p65, glucose-regulated protein (Grp78) and C\/EBP homologous protein (CHOP) expression. IH also induced apoptosis and increased infarct size after I\/R . The IH-induced HIF-1 activation, oxidative stress, inflammation, ER stress and apoptosis were abolished by chronic Curc treatment. Curc also significantly decreased infarct size only in mice exposed to IH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Curc prevents IH-induced myocardial cell death signalling. Curc might be used as a combined therapy with continuous positive airway pressure in sleep apnoea patients with high cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2040622320922104","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T11:02:10Z","timestamp":1592996530000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Curcumin prevents chronic intermittent hypoxia-induced myocardial injury"],"prefix":"10.1177","volume":"11","author":[{"given":"Sophie","family":"Moulin","sequence":"first","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes-HP2-Grenoble F-38042, France \/ INSERM, U1042-Grenoble F38042, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Arnaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes-HP2-Grenoble F-38042, France \/ INSERM, U1042-Grenoble F38042, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Bouyon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes-HP2-Grenoble F-38042, France \/ INSERM, U1042-Grenoble F38042, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"P\u00e9pin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes-HP2-Grenoble F-38042, France \/ INSERM, U1042-Grenoble F38042, France \/ Centre Hospitalier Universitaire des Alpes, Grenoble F38042, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Godin-Ribuot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes-HP2-Grenoble F-38042, France \/ INSERM, U1042-Grenoble F38042, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4589-1612","authenticated-orcid":false,"given":"Elise","family":"Belaidi","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, Grenoble, France INSERM, U1042, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"bibr1-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-307855"},{"key":"bibr2-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30198-5"},{"key":"bibr3-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3407"},{"key":"bibr4-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.09.014"},{"key":"bibr5-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029400"},{"key":"bibr6-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht450"},{"key":"bibr7-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.15"},{"key":"bibr8-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.07.010"},{"key":"bibr9-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0006-2019"},{"key":"bibr10-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.05.004"},{"key":"bibr11-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00045.2008"},{"key":"bibr12-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00641.2015"},{"key":"bibr13-2040622320922104","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.02.096"},{"key":"bibr14-2040622320922104","doi-asserted-by":"crossref","unstructured":"Moulin S, Thomas A, Arnaud C, et al. 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