{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:16:36Z","timestamp":1790712996175,"version":"4.1.0"},"reference-count":66,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"Taiwan National Science Council","doi-asserted-by":"crossref","award":["104-2314-B-002-125-MY3, 106-2314-B-002 -166 -MY3,107-2314-B-002-026-MY3"],"award-info":[{"award-number":["104-2314-B-002-125-MY3, 106-2314-B-002 -166 -MY3,107-2314-B-002-026-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004737","name":"national health research institutes","doi-asserted-by":"publisher","award":["PH-102-SP-09"],"award-info":[{"award-number":["PH-102-SP-09"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"national taiwan university hospital","doi-asserted-by":"publisher","award":["106-FTN20, 106-P02, UN106-014, 106-S3582,"],"award-info":[{"award-number":["106-FTN20, 106-P02, UN106-014, 106-S3582,"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology (MOST) of the Republic of China (Taiwan","award":["106-2321-B-182-002"],"award-info":[{"award-number":["106-2321-B-182-002"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Chronic Disease"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In primary aldosteronism (PA), kidney function impairment could be concealed by relative hyperfiltration and emerge after adrenalectomy. We hypothesized transtubular gradient potassium gradient (TTKG), a kidney aldosterone bioactivity indicator, could correlate to end organ damage and forecast kidney function impairment after adrenalectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In the present prospective study, we enrolled lateralized PA patients who underwent adrenalectomy and were followed up 12\u2009months after operation in the Taiwan Primary Aldosteronism Investigation (TAIPAI) registry from 2010 to 2018. The clinical outcome was kidney function impairment, defined as estimated glomerular filtration rate (eGFR) &lt;60\u2009ml\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      at 12\u2009months after adrenalectomy. End organ damage is determined by microalbuminuria and left ventricular mass.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 323 patients [mean, 50.8\u2009\u00b1\u200910.9\u2009years old; female 178 (55.1%)] were enrolled. Comparing pre-operation and post-operation data, systolic blood pressure, serum aldosterone, urinary albumin to creatinine ratio and eGFR decreased. TTKG\u2009\u2a7e\u20094.9 correlated with pre-operative urinary albumin to creatinine ratio &gt;50\u2009mg\/g [odds ratio (OR)\u2009=\u20092.42; p\u2009=\u20090.034] and left ventricular mass (B\u2009=\u200920.10; p\u2009=\u20090.018). Multivariate logistic regression analysis demonstrated that TTKG\u2009\u2a7e\u20094.9 could predict concealed chronic kidney disease (OR\u2009=\u20095.42; p\u2009=\u20090.011) and clinical success (OR\u2009=\u20092.90, p\u2009=\u20090.017) at 12\u2009months after adrenalectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>TTKG could predict concealed kidney function impairment and cure of hypertension in PA patients after adrenalectomy. TTKG more than 4.9 as an adverse surrogate of aldosterone and hypokalaemia correlated with pre-operative end organ damage in terms of high proteinuria and cardiac hypertrophy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2040622320944792","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T04:08:51Z","timestamp":1598501331000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Transtubular potassium gradient predicts kidney function impairment after adrenalectomy in primary aldosteronism"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3090-1937","authenticated-orcid":false,"given":"Hung-Wei","family":"Liao","sequence":"first","affiliation":[{"name":"Chinru Clinic, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo-Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, National Taiwan University Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Kai","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu branch, Hsin-Chu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Chih","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hsun","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Far Eastern Polyclinic, Taipei City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff S","family":"Chueh","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute, and Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin-Cent","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Room 1555, Clinical Research Building, 7 Chung-Shan South Road, Taipei 100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai-Shuan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kao-Lang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Chiag","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-How","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Cheng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoh-Fang","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leay-Kiaw","family":"Er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Hsiung","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Chou","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chieh Jeff","family":"Chueh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chieh","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan-Dun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"bibr1-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60834-X"},{"key":"bibr2-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-011-9161-9"},{"key":"bibr3-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.052"},{"key":"bibr4-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000230444.01215.6a"},{"key":"bibr5-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.015"},{"key":"bibr6-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.07.059"},{"key":"bibr7-2040622320944792","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00050107"},{"key":"bibr8-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.22.2638"},{"key":"bibr9-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070123"},{"key":"bibr10-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.1.232"},{"key":"bibr11-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00532.2009"},{"key":"bibr12-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004100878"},{"key":"bibr13-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs037"},{"key":"bibr14-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1177\/1470320310391331"},{"key":"bibr15-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1177\/1470320315595568"},{"key":"bibr16-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12029"},{"key":"bibr17-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12914"},{"key":"bibr18-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00970.x"},{"key":"bibr19-2040622320944792","first-page":"120","volume":"13","author":"Joo KW","year":"2000","journal-title":"J Nephrol"},{"key":"bibr20-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-0437"},{"key":"bibr21-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1007\/BF00858819"},{"key":"bibr22-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283495cbb"},{"key":"bibr23-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1135"},{"key":"bibr24-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1038\/srep11396"},{"key":"bibr25-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.06.014"},{"key":"bibr26-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.02.018"},{"key":"bibr27-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.89"},{"key":"bibr28-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2017.06.004"},{"key":"bibr29-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00746"},{"key":"bibr30-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1038\/srep32103"},{"key":"bibr31-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.05.001"},{"key":"bibr32-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2014.05.012"},{"key":"bibr33-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.01.027"},{"key":"bibr34-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067417"},{"key":"bibr35-2040622320944792","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.064873"},{"key":"bibr36-2040622320944792","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17505"},{"key":"bibr37-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"bibr38-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000083982.74108.54"},{"key":"bibr39-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1038\/srep15297"},{"key":"bibr40-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12497"},{"key":"bibr41-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1038\/srep26335"},{"key":"bibr42-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2035-8"},{"key":"bibr43-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.16326"},{"key":"bibr44-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80076-X"},{"key":"bibr45-2040622320944792","first-page":"551","volume":"18","author":"Musso C","year":"2007","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"bibr46-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.08314"},{"key":"bibr47-2040622320944792","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S46674"},{"key":"bibr48-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.175"},{"key":"bibr49-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008010021"},{"key":"bibr50-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004667"},{"key":"bibr51-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00125.2011"},{"key":"bibr52-2040622320944792","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/587359"},{"key":"bibr53-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00631.2014"},{"key":"bibr54-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00358.2017"},{"key":"bibr55-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.12.017"},{"key":"bibr56-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00254.2010"},{"key":"bibr57-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0688-8"},{"key":"bibr58-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-011-0727-5"},{"key":"bibr59-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.01.012"},{"key":"bibr60-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2010.09.004"},{"key":"bibr61-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015010022"},{"key":"bibr62-2040622320944792","doi-asserted-by":"crossref","first-page":"e0195784","DOI":"10.1371\/journal.pone.0195784","volume":"13","author":"Lee SM","year":"2018","journal-title":"PLoS One"},{"key":"bibr63-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00389.x"},{"key":"bibr64-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91047-2"},{"key":"bibr65-2040622320944792","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07271009"},{"key":"bibr66-2040622320944792","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30135-3"}],"container-title":["Therapeutic Advances in Chronic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2040622320944792","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2040622320944792","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2040622320944792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:18:06Z","timestamp":1777591086000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2040622320944792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":66,"alternative-id":["10.1177\/2040622320944792"],"URL":"https:\/\/doi.org\/10.1177\/2040622320944792","relation":{},"ISSN":["2040-6223","2040-6231"],"issn-type":[{"value":"2040-6223","type":"print"},{"value":"2040-6231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2040622320944792"}}