{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:43:35Z","timestamp":1788533015032,"version":"build-2803163510"},"reference-count":52,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"Taiwan National Science Council","doi-asserted-by":"crossref","award":["104-2314-B-002-125-MY3, 106-2314-B-002 -166 -MY3,107-2314-B-002-026-MY3"],"award-info":[{"award-number":["104-2314-B-002-125-MY3, 106-2314-B-002 -166 -MY3,107-2314-B-002-026-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004737","name":"national health research institutes","doi-asserted-by":"publisher","award":["PH-102-SP-09"],"award-info":[{"award-number":["PH-102-SP-09"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"national taiwan university hospital","doi-asserted-by":"publisher","award":["106-FTN20, 106-P02, UN106-014, 106-S3582, 107-S3809, 107-T02,PC1246,VN109-09,109-S4634,UN109-041"],"award-info":[{"award-number":["106-FTN20, 106-P02, UN106-014, 106-S3582, 107-S3809, 107-T02,PC1246,VN109-09,109-S4634,UN109-041"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"ministry of science and technology of the people\u2019s republic of china","doi-asserted-by":"publisher","award":["106-FTN20, 106-P02, UN106-014, 106-S3582, 107-S3809, 107-T02,PC1246,VN109-09,109-S4634,UN109-041"],"award-info":[{"award-number":["106-FTN20, 106-P02, UN106-014, 106-S3582, 107-S3809, 107-T02,PC1246,VN109-09,109-S4634,UN109-041"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Chronic Disease"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Elevated plasma C-terminal fibroblast growth factor-23 (cFGF-23) levels are associated with higher mortality in patients with chronic kidney disease (CKD) and acute kidney injury (AKI). Our study explored the outcome forecasting accuracy of cFGF-23 in critically ill patients with CKD superimposed with AKI (ACKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Urine and plasma biomarkers from 149 CKD patients superimposed with AKI before dialysis were checked in this multicenter prospective observational cohort study. Endpoints were 90-day mortality and 90\u2009days free from dialysis after hospital discharge. Associations with study endpoints were assessed using hierarchical clustering analysis, the generalized additive model, the Cox proportional hazard model, competing risk analysis, and discrimination evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Over a median follow up of 40\u2009days, 67 (45.0%) patients died before the 90th day after hospital discharge and 39 (26.2%) progressed to kidney failure with replacement therapy (KFRT). Hierarchical clustering analysis demonstrated that cFGF-23 levels had better predictive ability for 90-day mortality than did other biomarkers. Higher serum cFGF-23 levels were independently associated with greater risk for 90-day mortality [hazard ratio (HR): 2.5; 95% confidence interval (CI) 1.5\u20134.1; p\u2009&lt;\u20090.001]. Moreover, adding plasma cFGF-23 to the Demirjian AKI risk score model substantially improved risk prediction for 90-day mortality than the Demirjian model alone (integrated discrimination improvement: 0.06; p\u2009&lt;\u20090.05; 95% CI 0.02\u20130.10). The low plasma cFGF-23 group was predicted having more weaning from dialysis in surviving patients (HR\u2009=\u20090.53, 95% CI, 0.29\u20130.95, p\u2009=\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In patients with ACKD, plasma cFGF-23 levels are an independent risk factor to forecast 90-day mortality and 90-day progression to KFRT. In combination with the clinical risk score, plasma cFGF-23 levels could substantially improve mortality risk prediction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2040622320964161","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:59:13Z","timestamp":1602637153000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["High plasma C-terminal FGF-23 levels predict poor outcomes in patients with chronic kidney disease superimposed with acute kidney injury"],"prefix":"10.1177","volume":"11","author":[{"given":"Yu-Hsing","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Nephrology, National Taiwan University Hospital, Taipei NSARF Group (National Taiwan University Hospital Study Group of ARF), Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6164-6655","authenticated-orcid":false,"given":"Che-Hsiung","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City School of Medicine, Tzu Chi University, Hualien NSARF Group (National Taiwan University Hospital Study Group of ARF), Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Kuan","family":"Chou","sequence":"additional","affiliation":[{"name":"Division of Surgery, National Taiwan University Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jung","family":"Tseng","sequence":"additional","affiliation":[{"name":"Division of Surgery, National Taiwan University Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"i-Ping","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Surgery, National Taiwan University Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsien","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Surgery, National Taiwan University Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin-Cent","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Room 1555, Clinical Research Building, 7 Chung-Shan South Road, Taipei 100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong-Shinn","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, National Taiwan University Hospital, Taipei NSARF Group (National Taiwan University Hospital Study Group of ARF), 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