{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T21:44:22Z","timestamp":1779140662379,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Chronic Disease"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Occasional findings of anti-cyclic-citrullinated-protein-antibodies (anti-CCP) were rarely observed in psoriatic arthritis (PsA). The aim of our study is to evaluate whether the presence of anti-CCP can determine different clinical subsets and influence methotrexate monotherapy survival, and biotechnological drug retention rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective study on PsA patients. All patients were required to fulfill the CASPAR criteria for PsA, and to present juxta-articular osteo-proliferative signs at X-ray. The exclusion criteria were age less than 18\u2009years old, satisfaction of rheumatoid arthritis classification criteria, and seropositivity for rheumatoid factor. Clinical characteristics, anti-CCP titer, drug survival and comorbidities information were recorded for each patient. Statistical signi\ufb01cance was set at p\u2009\u2a7d\u20090.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 407 patients with PsA screened 113 were recruited. Twelve patients were anti-CCP positive. Methotrexate monotherapy survival was shorter in patients with anti-CCP (150\u2009\u00b1\u200948.3\u2009weeks versus 535.3\u2009\u00b1\u200965.3\u2009weeks; p\u2009=\u20090.026) [discontinuation risk hazard ratio (HR)\u2009=\u20092.389, 95% confidence interval (CI) 1.043, 5.473; p\u2009=\u20090.039] than those without. Significant shorter survival of first-line biotechnological drugs (b-DMARDs) was observed in the anti-CCP positive group than in that without (102.05\u2009\u00b1\u200924.4\u2009weeks versus 271.6\u2009\u00b1\u200941.7\u2009weeks; p\u2009=\u20090.005) with higher discontinuation risk (HR\u2009=\u20093.230, 95% CI 1.299, 8.028; p\u2009=\u20090.012). A significant higher rate of multi-failure (more than second-line b-DMARDs) was found in anti-CCP positive patients than in those without (50% versus 14%, p\u2009=\u20090.035).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Anti-CCP in PsA could be suggestive of more severe disease, with worse drug survival of both methotrexate monotherapy and first-line b-DMARDs, and higher chance to be b-DMARDs multi-failure. So, they can be considered for more intensive clinical management of these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2040622320986722","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:37:06Z","timestamp":1612226226000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Anti-cyclic-citrullinated-protein-antibodies in psoriatic arthritis patients: how autoimmune dysregulation could affect clinical characteristics, retention rate of methotrexate monotherapy and first line biotechnological drug survival. A single center retrospective study."],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1356-8423","authenticated-orcid":false,"given":"Cinzia","family":"Rotondo","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences \u2013 Rheumatology Unit, University of Foggia, Foggia viale Luigi Pinto 1, Foggia, 71122, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Addolorata","family":"Corrado","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences \u2013 Rheumatology Unit, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Cici","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences \u2013 Rheumatology Unit, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Berardi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences \u2013 Rheumatology Unit, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco Paolo","family":"Cantatore","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences \u2013 Rheumatology Unit, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"bibr1-2040622320986722","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03361.x"},{"key":"bibr2-2040622320986722","first-page":"210","volume":"33","author":"Scarpa R","year":"2006","journal-title":"J Rheumatol"},{"key":"bibr3-2040622320986722","first-page":"1","volume":"13","author":"Kourosh AS","year":"2008","journal-title":"Ski Ther 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