{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:06:23Z","timestamp":1777878383759,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Taiwan University Hospital, Hsin-Chu branch","award":["110-HCH045"],"award-info":[{"award-number":["110-HCH045"]}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG1E0061"],"award-info":[{"award-number":["CMRPG1E0061"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG1E0062"],"award-info":[{"award-number":["CMRPG1E0062"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG1F0161"],"award-info":[{"award-number":["CMRPG1F0161"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG1G0121"],"award-info":[{"award-number":["CMRPG1G0121"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Chronic Disease"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Numerous previous studies have examined risk of herpes zoster (HZ) in psoriatic disease; however, the results of these studies are conflicting and the relative risks associated with different treatments remain largely unknown. In this meta-analysis, we examined the relative risk of HZ associated with systemic treatments for psoriatic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched to identify relevant English-language studies published up to April 2021. Data were extracted using a standardized data extraction form. Network meta-analyses (NMA) was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. We examined the differences in HZ risk (incidence rate ratio; IRR) between treatments using a random-effects model for direct pairwise comparisons and NMA. The surface under the cumulative ranking area was calculated to rank the HZ risk for each treatment condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>This study analyzed 13 studies including 19 treatment arms involving a total of 443,104 patients with psoriatic disease. Corticosteroids (CS) [IRR, 2.56; 95% confidence interval (CI), 1.59\u20134.13], a Janus kinase inhibitor (JAKi; tofacitinib) (IRR, 2.34; 95% CI, 1.03\u20135.32), infliximab (IRR, 2.32; 95% CI, 1.27\u20134.21), conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs)\u2009+\u2009CS (IRR, 2.26; 95% CI, 1.23\u20134.17), anti-tumor necrosis factor-\u03b1 (anti-TNF-\u03b1)\u2009+\u2009csDMARDs and\/or CS (IRR, 2.13; 95% CI, 1.38\u20133.31), csDMARDs (IRR, 1.62; 95% CI, 1.18\u20132.22), and anti-TNF-\u03b1 except infliximab (IRR, 1.61; 95% CI, 1.13\u20132.30) were all associated with a significantly higher HZ risk compared to controls. CS treatment possessed the highest HZ risk, followed by infliximab and JAKi (tofacitinib). Phosphodiesterase-4 inhibitor, anti-interleukin-17, -23 or -12\/23, phototherapy, and acitretin showed a risk similar to controls without significant differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The NMA demonstrated CS, infliximab, and JAKi (tofacitinib), and several combination treatments were associated with higher HZ risk in patients with psoriasis and psoriatic arthritis. Differences in HZ risk should be taken into consideration when considering optimal psoriasis treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20406223221091188","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T09:40:17Z","timestamp":1651484417000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparative risk of herpes zoster in patients with psoriatic disease on systemic treatments: a systematic review and network meta-analysis"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0493-9707","authenticated-orcid":false,"given":"Hsien-Yi","family":"Chiu","sequence":"first","affiliation":[{"name":"Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu"},{"name":"Department of Dermatology, National Taiwan University Hospital, Taipei"},{"name":"Department of Dermatology, College of Medicine, National Taiwan University, Taipei"},{"name":"Department of Medical Research, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1759-7790","authenticated-orcid":false,"given":"Yi-Teng","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chang Gung Memorial Hospital Linkou Branch, Taoyuan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, National Taiwan University Hospital Yunlin Branch, Douliu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0574-1839","authenticated-orcid":false,"given":"Yu-Huei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chang Gung Memorial Hospital Linkou Branch, No.5, Fuxing St., Guishan Dist., Taoyuan City 333"},{"name":"School of Medicine, College of Medicine, Chang Gung University, Taoyuan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"bibr1-20406223221091188","doi-asserted-by":"publisher","DOI":"10.1086\/379048"},{"key":"bibr2-20406223221091188","doi-asserted-by":"publisher","DOI":"10.1002\/art.39670"},{"key":"bibr3-20406223221091188","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179447"},{"key":"bibr4-20406223221091188","doi-asserted-by":"publisher","DOI":"10.1002\/art.23112"},{"key":"bibr5-20406223221091188","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014032"},{"key":"bibr6-20406223221091188","first-page":"6222","volume":"14","author":"Chen D","year":"2017","journal-title":"Exp Ther 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