{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:06:31Z","timestamp":1777878391392,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871299"],"award-info":[{"award-number":["81871299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171800"],"award-info":[{"award-number":["82171800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Chronic Disease"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the effectiveness and safety of low-dose interferon alpha-2a (IFN\u03b12a) in Beh\u00e7et\u2019s syndrome (BS) patients with refractory vascular\/cardiac or neurological involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this retrospective cohort study, we consecutively included 25 BS patients with refractory vascular\/cardiac ( n\u2009=\u200916) or neurological involvement ( n\u2009=\u20099) who received IFN\u03b12a treatment in our center between June 2018 and September 2021. The low-dose IFN\u03b12a (3\u2009million IU, every other day) was used as an add-on treatment with the continuation of glucocorticoids (GCs) and immunosuppressants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 25 patients (20 males, 5 females) with a mean age of 31.92\u2009\u00b1\u20099.25\u2009years were included. IFN\u03b12a was administered for BS patients with refractory vascular\/cardiac involvement ( n\u2009=\u200916) and neurological involvement ( n\u2009=\u20099). Before the initiation of IFN\u03b12a, patients had insufficient response or intolerance to conventional therapies. After a median follow-up of 23 [interquartile range (IQR), 11\u201330]\u2009months, all patients achieved clinical improvement. The Beh\u00e7et\u2019s disease Current Activity Form (BDCAF) score improved significantly (5 versus 0, median, p\u2009&lt;\u20090.0001). BS Overall Damage Index (BODI) and vasculitis damage index (VDI) remain stable ( p\u2009&gt;\u20090.05). Decrease in erythrocyte sedimentation rate [ESR; 24 (IQR, 12\u201343.5) versus 5 (IQR, 2.75\u201310.5)\u2009mm\/h, p\u2009=\u20090.0001] and C-reactive protein [CRP; 6.64 (IQR, 3.67\u201319.82) versus 1.24 (IQR, 0.24\u20133.12)\u2009mg\/liter, p\u2009&lt;\u20090.005] was achieved effectively. The median GCs dosage tapered from 26.25 (IQR, 11.88\u201341.25) to 10.00 (IQR, 7.50\u201310.63)\u2009mg\/d, p\u2009&lt;\u20090.0001. Immunosuppressants were also reduced in number ( p\u2009&lt;\u20090.005). No serious adverse events were observed during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study suggests that low-dose IFN\u03b12a, combined with GCs and immunosuppressants, is well-tolerated and effective for BS patients with refractory vascular\/cardiac or neurological involvement and has a steroid- and immunosuppressant-sparing effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20406223221111285","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T01:43:45Z","timestamp":1658886225000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness and safety of low-dose interferon alpha-2a treatment in Beh\u00e7et\u2019s Syndrome with refractory vascular or neurological involvement: a case series"],"prefix":"10.1177","volume":"13","author":[{"given":"Luxi","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Centre for Tuberculosis Research, Clinical Epidemiology Unit, International Epidemiology Network, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JinJing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Nursing, Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Centre for Tuberculosis Research, Clinical Epidemiology Unit, International Epidemiology Network, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Complex 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