{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:06:52Z","timestamp":1790996812402,"version":"4.1.0"},"reference-count":52,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Taiwan University Hospital, Hsin-Chu branch","award":["111-HCH004, 111-HCH108"],"award-info":[{"award-number":["111-HCH004, 111-HCH108"]}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2314-B-002-191, MOST 111-2314-B-002-244"],"award-info":[{"award-number":["MOST 110-2314-B-002-191, MOST 111-2314-B-002-244"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Chronic Disease"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with psoriasis have a significant disease burden throughout the life course. Nevertheless, the lifetime risk and disease burden of psoriasis across the entire lifespan is rarely quantified in an easily understandable way.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To estimate the cumulative incidence rate, life expectancy, loss-of-life expectancy, and lifetime healthcare expenditures for incident psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and methods:<\/jats:title>\n                    <jats:p>Using real-world nationwide data from the National Health Insurance Research Database of Taiwan for 2000\u20132017, along with the life tables of vital statistics, we estimated cumulative incidence rate, life expectancy, loss-of-life expectancy, and lifetime healthcare expenditures for those with psoriasis using a semi-parametric survival extrapolation method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 217,924 new psoriasis cases were identified. The lifetime risk of psoriasis in patients aged 18\u201380 for both sexes decreased in Taiwan with a cumulative incidence rate of 7.93% in 2000 to 3.25% in 2017. The mean (\u00b1standard error) life expectancy after diagnosis was 27.11 (\u00b1\u20091.15) and 27.14 (\u00b11.17) years for patients with moderate-to-severe psoriasis and psoriatic arthritis, respectively. Patients with moderate-to-severe psoriasis and psoriatic arthritis had a mean (\u00b1standard error) loss-of-life expectancy of 6.41 (\u00b11.16) and 6.48 (\u00b11.17) due to psoriasis, respectively. Male patients have higher lifetime and annual lifetime healthcare expenditures than female. Mean life expectancy, loss-of-life expectancy, and lifetime cost were relatively higher for younger patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Among psoriatic patients, patients with moderate-to-severe psoriasis and psoriatic arthritis had substantial years of life lost, particularly for younger patients. Our results provide a reliable estimation of lifetime disease burden, and these estimates will help health authorities in cost-effectiveness assessments of public health interventions and allocation of services resources to minimize loss-of-life expectancy, and lifetime healthcare expenditures in patients with psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20406223231168488","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T02:43:56Z","timestamp":1682736236000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Lifetime risk, life expectancy, loss-of-life expectancy, and lifetime healthcare expenditures for psoriasis in Taiwan: a nationwide cohort followed from 2000 to 2017"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0493-9707","authenticated-orcid":false,"given":"Hsien-Yi","family":"Chiu","sequence":"first","affiliation":[{"name":"Department of Dermatology, National Taiwan University Hsin-Chu Hospital, Hsinchu"},{"name":"Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu"},{"name":"Department of Dermatology, National Taiwan University Hospital, Taipei"},{"name":"Department of Dermatology, College of Medicine, National Taiwan University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joung-Liang","family":"Lan","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Center, China Medical University Hospital, Taichung City"},{"name":"Department of Medicine, China Medical University, Taichung City"},{"name":"Hsien-Yi Chiu is also affiliated to Department of Medical Research, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-5331","authenticated-orcid":false,"given":"Ying-Ming","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Allergy, Immunology, and Rheumatology, Tungs\u2019 Taichung MetroHarbor Hospital, No. 699, Section 8, Taiwan Boulevard, Wuqi District, Taichung City 43503"},{"name":"Department of Nursing, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung City"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"bibr1-20406223231168488","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10280.x"},{"key":"bibr2-20406223231168488","first-page":"809","volume":"95","author":"Svedbom A","year":"2015","journal-title":"Acta Derm 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