{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:43:17Z","timestamp":1788788597276,"version":"build-2803163510"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/00938 and CB22\/05\/00067"],"award-info":[{"award-number":["PI22\/00938 and CB22\/05\/00067"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RTI2018-102165-B-I00 and RTC2019-007373-1"],"award-info":[{"award-number":["RTI2018-102165-B-I00 and RTC2019-007373-1"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008425","name":"Conseller\u00eda de Cultura, Educaci\u00f3n e Ordenaci\u00f3n Universitaria, Xunta de Galicia","doi-asserted-by":"publisher","award":["IN607A2018\/3; IN607D 2020\/09 and IN607A2022\/07"],"award-info":[{"award-number":["IN607A2018\/3; IN607D 2020\/09 and IN607A2022\/07"]}],"id":[{"id":"10.13039\/501100008425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["INTERREG Atlantic Area (EAPA_791\/2018_ NEUROATLANT"],"award-info":[{"award-number":["INTERREG Atlantic Area (EAPA_791\/2018_ NEUROATLANT"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Chronic Disease"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>One of the main biological mechanisms behind the link between periodontitis and atherosclerotic vascular diseases is vascular endothelial dysfunction. Particularly, circulating endothelial progenitor cells (EPCs) have been considered a biomarker of altered vascular endothelial function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this study was to investigate relationship between periodontal inflammation and increased number of circulating EPCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this study, 85 elderly patients with a previous history of hypertension were followed up to 12\u2009months. A baseline full-mouth periodontal assessment was carried out, and the amount of periodontal tissue inflamed per subject was calculated as a proxy of periodontal inflammation [periodontal inflamed surface area (PISA)]. The number of circulating EPCs (CD34\n                      <jats:sup>+<\/jats:sup>\n                      \/CD133\n                      <jats:sup>+<\/jats:sup>\n                      \/KDR\n                      <jats:sup>+<\/jats:sup>\n                      ) was determined by flow cytometry from peripheral blood samples collected at baseline and 12\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean concentrations of CD34\n                      <jats:sup>+<\/jats:sup>\n                      \/CD133\n                      <jats:sup>+<\/jats:sup>\n                      \/KDR\n                      <jats:sup>+<\/jats:sup>\n                      progenitor cells were higher in periodontitis patients than in those without periodontitis at baseline [55.4, 95% confidence interval (CI)\u2009=\u200920.8 to 90.0 versus 27.2, 95% CI\u2009=\u200913.6 to 40.8, p\u2009=\u20090.008] and 12\u2009months (114.6, 95% CI\u2009=\u200953.5 to 175.7 versus 19.1, 95% CI\u2009=\u200910.8 to 27.4, p\u2009=\u20090.003). A significant increase over the follow-up was noticed in the group of subjects with periodontitis ( p\u2009=\u20090.049) but not in the nonperiodontitis group ( p\u2009=\u20090.819). PISA was independently associated with CD34\n                      <jats:sup>+<\/jats:sup>\n                      \/CD133\n                      <jats:sup>+<\/jats:sup>\n                      \/KDR\n                      <jats:sup>+<\/jats:sup>\n                      EPCs at baseline ( B coefficient\u2009=\u20090.031, 95% CI\u2009=\u20090.005 to 0.058; p\u2009=\u20090.021). The relationship between PISA and CD34\n                      <jats:sup>+<\/jats:sup>\n                      \/CD133\n                      <jats:sup>+<\/jats:sup>\n                      \/KDR\n                      <jats:sup>+<\/jats:sup>\n                      EPCs at 12\u2009months was confounded by increased baseline body mass index ( B coefficient\u2009=\u20090.064, 95% CI\u2009=\u2009\u22120.005 to 0.132; p\u2009=\u20090.066).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Periodontal inflammation is associated with high number of CD34\n                      <jats:sup>+<\/jats:sup>\n                      \/CD133\n                      <jats:sup>+<\/jats:sup>\n                      \/KDR\n                      <jats:sup>+<\/jats:sup>\n                      EPCs, thus supporting a potential link between periodontitis and endothelial dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20406223231178276","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T08:31:31Z","timestamp":1686645091000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Periodontal inflammation is associated with increased circulating levels of endothelial progenitor cells: a retrospective cohort study in a high vascular risk population"],"prefix":"10.1177","volume":"14","author":[{"given":"Mar\u00eda","family":"V\u00e1zquez-Reza","sequence":"first","affiliation":[{"name":"Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00eda","family":"Custodia","sequence":"additional","affiliation":[{"name":"NeuroAging Laboratory (NEURAL) Group, Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iria","family":"L\u00f3pez-Dequidt","sequence":"additional","affiliation":[{"name":"Neurology Department, University Clinical Hospital, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Aramburu-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"NeuroAging Laboratory (NEURAL) Group, Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Romaus-Sanjurjo","sequence":"additional","affiliation":[{"name":"NeuroAging Laboratory (NEURAL) Group, Clinical Neurosciences Research Laboratory 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Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Machado","sequence":"additional","affiliation":[{"name":"Periodontology Department and Evidence-Based Hub, Clinical Research Unit, Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Universit\u00e1rio Egas Moniz \u2013 Cooperativa de Ensino Superior, Caparica, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Iglesias-Rey","sequence":"additional","affiliation":[{"name":"Neuroimaging and Biotechnology Laboratory (NOBEL) Group, Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"P\u00edas-Peleteiro","sequence":"additional","affiliation":[{"name":"NeuroAging Laboratory (NEURAL) Group, Clinical Neurosciences Research Laboratory 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