{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:32:35Z","timestamp":1788413555525,"version":"build-2803163510"},"reference-count":55,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Chronic Disease"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Periodontitis and viral liver infections, particularly hepatitis B virus (HBV) and hepatitis C virus (HCV), are chronic inflammatory conditions with a high prevalence worldwide. Recent evidence establishes a possible bidirectional relationship between the two, based on shared immunological, microbial, and inflammatory mechanisms. The objective of this study was to analyze and synthesize the scientific literature on the interactions between viral hepatitis and periodontal health. Through a structured search of the PubMed, Scopus, and Web of Science databases, studies published in the last 20\u2009years that explored the link between viral hepatitis and periodontitis were integrated. The findings from the reviewed studies show consistent, positive associations between HBV and HCV viruses and a higher prevalence and severity of periodontitis. Some studies show increased levels of proinflammatory cytokines (such as IL-6 and TNF-\u03b1) and immune dysfunction in participants with both diseases. Additionally, viral markers (such as HBsAg and HCV RNA) have been identified in gingival crevicular fluid, suggesting the presence of oral viral reservoirs. Ultimately, scientific evidence suggests a bidirectional relationship between viral hepatitis and periodontitis, influenced by systemic inflammation, immunological alterations, and microbial dysbiosis. The collected data support the relevance of interdisciplinary management between medical and dental professionals in patients with viral liver conditions.<\/jats:p>","DOI":"10.1177\/20406223251368090","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T09:03:58Z","timestamp":1755680638000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Hepatitis and periodontal health: an emerging oral-liver axis"],"prefix":"10.1177","volume":"16","author":[{"given":"Ruth","family":"Rodr\u00edguez-Monta\u00f1o","sequence":"first","affiliation":[{"name":"Department of Health and Illness as an Individual and Collective Process, University Center of Tlajomulco, University of Guadalajara (CUTLAJO-UdeG), Guadalajara, Mexico"},{"name":"Institute of Research in Dentistry, Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Mart\u00ednez-Nieto","sequence":"additional","affiliation":[{"name":"Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Eder","family":"Gonz\u00e1lez-Alvarez","sequence":"additional","affiliation":[{"name":"Department of Medical and Life Sciences, La Ci\u00e9nega University Center, University of Guadalajara (CUCIENEGA-UdeG), Ocotl\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-7969","authenticated-orcid":false,"given":"Mario Alberto","family":"Alarc\u00f3n-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Institute of Research in Dentistry, Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara, Mexico"},{"name":"Molecular Biology in Medicine Program, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta Sarai","family":"Becerra-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Clinics, Los Altos University Center, University of Guadalajara (CUALTOS-UdeG), Tepatitl\u00e1n de Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-3205","authenticated-orcid":false,"given":"Artak","family":"Heboyan","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Str. 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