{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:12:10Z","timestamp":1777878730553,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Tissue Eng"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>We compared fascial wounds repaired with non-cross-linked intact porcine-derived acellular dermal matrix versus primary closure in a large-animal hernia model. Incisional hernias were created in Yucatan pigs and repaired after 3 weeks via open technique with suture-only primary closure or intraperitoneally placed porcine-derived acellular dermal matrix. Progressive changes in mechanical and biological properties of porcine-derived acellular dermal matrix and repair sites were assessed. Porcine-derived acellular dermal matrix\u2013repaired hernias of additional animals were evaluated 2 and 4 weeks post incision to assess porcine-derived acellular dermal matrix regenerative potential and biomechanical changes. Hernias repaired with primary closure showed substantially more scarring and bone hyperplasia along the incision line. Mechanical remodeling of porcine-derived acellular dermal matrix was noted over time. Porcine-derived acellular dermal matrix elastic modulus and ultimate tensile stress were similar to fascia at 6 weeks. The biology of porcine-derived acellular dermal matrix\u2013reinforced animals was more similar to native abdominal wall versus that with primary closure. In this study, porcine-derived acellular dermal matrix\u2013reinforced repairs provided more complete wound healing response compared with primary closure.<\/jats:p>","DOI":"10.1177\/2041731413508771","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T12:34:48Z","timestamp":1381494888000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Porcine incisional hernia model: Evaluation of biologically derived intact extracellular matrix repairs"],"prefix":"10.1177","volume":"4","author":[{"given":"Gary A","family":"Monteiro","sequence":"first","affiliation":[{"name":"LifeCell Corporation, Inc., Branchburg, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aubrey I","family":"Delossantos","sequence":"additional","affiliation":[{"name":"LifeCell Corporation, Inc., Branchburg, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil 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