{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:15:18Z","timestamp":1791198918711,"version":"4.1.0"},"reference-count":61,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Tissue Eng"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials. This study aimed to evaluate the histological and histomorphometric response of dentin\u2013pulp complex to the enamel matrix derivative (Emdogain\n                    <jats:sup>\u00ae<\/jats:sup>\n                    gel) compared to that of calcium hydroxide when used as a pulp dressing in immature young permanent dogs\u2019 teeth. Dentin-like tissues bridging the full width of the coronal pulp at the interface between the injured and healthy pulp tissues were seen after 1 month in both groups. With time, the dentin bridge increased in thickness for calcium hydroxide but disintegrated and fully disappeared for Emdogain-treated group. Progressive inflammation and total pulp degeneration were only evident with Emdogain-treated group. The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament. In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino\u2013pulpal complex regeneration.\n                  <\/jats:p>","DOI":"10.1177\/2041731414521707","type":"journal-article","created":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T22:09:05Z","timestamp":1391465345000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Root maturation and dentin\u2013pulp response to enamel matrix derivative in pulpotomized permanent teeth"],"prefix":"10.1177","volume":"5","author":[{"given":"Sherif S","family":"Darwish","sequence":"first","affiliation":[{"name":"Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Pharos University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadia H","family":"Abd El Meguid","sequence":"additional","affiliation":[{"name":"Oral Biology Department, King Abdulaziz University, Jeddah, Saudi Arabia"},{"name":"Oral Biology Department, Faculty of Dentistry, Alexandria University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia A","family":"Wahba","sequence":"additional","affiliation":[{"name":"Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A-R","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Chrzanowski","sequence":"additional","affiliation":[{"name":"The Faculty of Pharmacy, The University of Sydney, NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ensanya A","family":"Abou Neel","sequence":"additional","affiliation":[{"name":"Division of Biomaterials, Conservative 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