{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:26:12Z","timestamp":1784078772533,"version":"3.55.0"},"reference-count":70,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the National Research Foundation of Kore","award":["NRF-2018R1D1A1B0704292"],"award-info":[{"award-number":["NRF-2018R1D1A1B0704292"]}]},{"name":"Ministry of Science, ICT & Future Planning","award":["2015R1C1A1A01052127"],"award-info":[{"award-number":["2015R1C1A1A01052127"]}]},{"name":"Global Research Development Center Program","award":["NRF-2018K1A4A3A01064257"],"award-info":[{"award-number":["NRF-2018K1A4A3A01064257"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Tissue Eng"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Auditory function takes a major part in human life. While sensorineural hearing loss is related with many factors including genetic disorders, age and noise, the clear causes are not well understood. Even more, the currently available treatments with drugs cause side effects, which thus are considered suboptimal. Here, we communicate the delivery systems with biomaterials that can be possible therapeutic options to restore hearing and vestibular functions. We introduce briefly the various pathological factors related with hearing loss and the limitation of current therapies, detail the recent studies on delivery systems including nanoparticles and hydrogels and discuss future clinical availability.<\/jats:p>","DOI":"10.1177\/2041731418808455","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T07:33:08Z","timestamp":1540884788000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Auditory disorders and future therapies with delivery systems"],"prefix":"10.1177","volume":"9","author":[{"given":"Jung-Hwan","family":"Lee","sequence":"first","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea"},{"name":"Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, Republic of Korea"},{"name":"UCL Eastman \u2013 Korea Dental Medicine Innovation Center, Dankook University, Cheonan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute Korea, College of Medicine, Dankook University, Cheonan, Republic of Korea"},{"name":"Department of Otolaryngology-Head &amp; Neck Surgery, College of Medicine, Dankook University, Cheonan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Lim","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Knowles","sequence":"additional","affiliation":[{"name":"UCL Eastman \u2013 Korea Dental Medicine Innovation Center, Dankook University, Cheonan, Republic of Korea"},{"name":"Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea"},{"name":"Biomaterials and Tissue Engineering Research Department, UCL Eastman Dental Institute, London, UK"},{"name":"The Discoveries Centre for Regenerative and Precision Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea"},{"name":"Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, Republic of Korea"},{"name":"UCL Eastman \u2013 Korea Dental Medicine Innovation Center, Dankook University, Cheonan, Republic of Korea"},{"name":"Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1193"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0926"},{"issue":"12","key":"e_1_3_2_4_2","first-page":"19","article-title":"Detection and clinical diagnosis of noise-induced hearing loss by otoacoustic emissions","volume":"3","author":"Attias J","year":"2001","unstructured":"Attias J, Horovitz G, El-Hatib N, et al. Detection and clinical diagnosis of noise-induced hearing loss by otoacoustic emissions. Noise Health 2001; 3(12): 19\u201331.","journal-title":"Noise Health"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.22565"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004133421506"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60522-3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24332"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2426"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl205"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200831"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3801"},{"issue":"8","key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1136\/jmg.36.8.595","article-title":"Prevalence, age of onset, and natural history of thyroid disease in Pendred syndrome","volume":"36","author":"Reardon W","year":"1999","unstructured":"Reardon W, Coffey R, Chowdhury T, et al. Prevalence, age of onset, and natural history of thyroid disease in Pendred syndrome. J Med Genet 1999; 36(8): 595\u2013598.","journal-title":"J Med Genet"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297-411"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9727"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.024208"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00308"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxics3030268"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22576"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/2331216517753548"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e31828e86e8"},{"key":"e_1_3_2_22_2","article-title":"Biomaterials in cochlear implants","volume":"8","author":"St\u00f6ver T","year":"2009","unstructured":"St\u00f6ver T, Lenarz T. Biomaterials in cochlear implants. GMS Curr Top Otorhinolaryngol Head Neck Surg 2009; 8: Doc10.","journal-title":"GMS Curr Top Otorhinolaryngol Head Neck Surg"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2010-0535"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000241892"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/150637"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3098230"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/2041731417719170"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/2041731417707339"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920010794479673"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.12.5"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/238428"},{"issue":"4","key":"e_1_3_2_32_2","first-page":"735","article-title":"PEGylation of nanoparticles improves their cytoplasmic transport","volume":"2","author":"Suh J","year":"2007","unstructured":"Suh J, Choy K-L, Lai SK, et al. PEGylation of nanoparticles improves their cytoplasmic transport. Int J Nanomedicine 2007; 2(4): 735\u2013741.","journal-title":"Int J Nanomedicine"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S116867"},{"key":"e_1_3_2_34_2","first-page":"3567","article-title":"A single dose of dexamethasone encapsulated in polyethylene glycol-coated polylactic acid nanoparticles attenuates cisplatin-induced hearing loss following round window membrane administration","volume":"10","author":"Sun C","year":"2015","unstructured":"Sun C, Wang X, Zheng Z, et al. A single dose of dexamethasone encapsulated in polyethylene glycol-coated polylactic acid nanoparticles attenuates cisplatin-induced hearing loss following round window membrane administration. Int J Nanomedicine 2015; 10: 3567\u20133579.","journal-title":"Int J Nanomedicine"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.04.038"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-009-9768-0"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.04.028"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-012-1395-7"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00577-7"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201200634"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.14858"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1159\/000089407"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3155-8-32"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.11.021"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.12.036"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302312"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200701316"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja710193c"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.2217\/17435889.2.1.99"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200700941"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc0601267"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.14.214"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150531165059"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1177\/2041731417726464"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc500375r"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.940091"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3839"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3586"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2012.12.010"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00203-4"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567201811666140118224616"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104564"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.11.052"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8137614"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3781"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2015.150"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab1996"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.05.019"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.02.004"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700472"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3054"}],"container-title":["Journal of Tissue Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2041731418808455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2041731418808455","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2041731418808455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:27:24Z","timestamp":1777591644000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2041731418808455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":70,"alternative-id":["10.1177\/2041731418808455"],"URL":"https:\/\/doi.org\/10.1177\/2041731418808455","relation":{},"ISSN":["2041-7314","2041-7314"],"issn-type":[{"value":"2041-7314","type":"print"},{"value":"2041-7314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"article-number":"2041731418808455"}}