{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:05:30Z","timestamp":1782237930005,"version":"3.54.5"},"reference-count":64,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100011011","name":"junta de andaluc\u00eda","doi-asserted-by":"publisher","award":["CTS-259"],"award-info":[{"award-number":["CTS-259"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"junta de andaluc\u00eda","doi-asserted-by":"publisher","award":["FQM134"],"award-info":[{"award-number":["FQM134"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Feder"},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/G020579\/1"],"award-info":[{"award-number":["BB\/G020579\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/L021072\/1"],"award-info":[{"award-number":["BB\/L021072\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["AGL2017-89342-P"],"award-info":[{"award-number":["AGL2017-89342-P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["CTQ2016-78703-P"],"award-info":[{"award-number":["CTQ2016-78703-P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000739","name":"University of Southampton","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Tissue Eng"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Recent studies have shown that dietary patterns confer protection from certain chronic diseases related to oxidative stress, the immune system and chronic low-grade inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory potential and the capacity to attenuate cartilage degradation using extra-virgin olive oil\u2013derived polyphenols for the treatment of osteoarthritis. Results show that both nutraceuticals ligstroside aglycone and acetylated ligstroside aglycone showed an anti-inflammatory profile. Acetylated ligstroside aglycone significantly reduced the expression of pro-inflammatory genes including NOS2 and MMP13 at both RNA and protein levels; decreased nitric oxide release; and, importantly, reduced proteoglycan loss in human osteoarthritis cartilage explants. Our study demonstrated that a new synthetic acetylated ligstroside aglycone derivative offers enhanced anti-inflammatory profile than the natural nutraceutical compound in osteoarthritis. These results substantiate the role of nutraceuticals in osteoarthritis with implications for therapeutic intervention and our understanding of osteoarthritis pathophysiology.<\/jats:p>","DOI":"10.1177\/2041731420922701","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T02:42:40Z","timestamp":1590633760000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-6356","authenticated-orcid":false,"given":"Mar\u00eda C","family":"de Andr\u00e9s","sequence":"first","affiliation":[{"name":"Bone and Joint Research Group, Centre for Human Development Stem Cells and Regeneration, Institute of Developmental Science, University of Southampton, Southampton, UK"},{"name":"Cartilage Epigenetics Group, Rheumatology Division, INIBIC-Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia S","family":"Meiss","sequence":"additional","affiliation":[{"name":"Bone and Joint Research Group, Centre for Human Development Stem Cells and Regeneration, Institute of Developmental Science, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"S\u00e1nchez-Hidalgo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, University of Seville, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gonz\u00e1lez-Benjumea","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G","family":"Fern\u00e1ndez-Bola\u00f1os","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Alarc\u00f3n-de-la-Lastra","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, University of Seville, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-6726","authenticated-orcid":false,"given":"Richard OC","family":"Oreffo","sequence":"additional","affiliation":[{"name":"Bone and Joint Research Group, Centre for Human Development Stem Cells and Regeneration, Institute of Developmental Science, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34453"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1941738109350438"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200103)44:3<585::AID-ANR107>3.0.CO;2-C"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/2041731419842431"},{"key":"e_1_3_3_7_2","first-page":"204173141982779","article-title":"A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation \u2013 I: the effects of growth factors","volume":"10","author":"Campbell K","year":"2019","unstructured":"Campbell K, Naire S, Kuiper JH. A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation \u2013 I: the effects of growth factors. J Tissue Eng 2019; 10: 2041731419827791.","journal-title":"J Tissue Eng"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.11.021"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871530314666140922153350"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.136390"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.09.035"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665113003935"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060843"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","unstructured":"Dudeja P Gupta RK. Chapter 40 \u2013 nutraceuticals. In: Gupta RK Dufeja S Minhas S (eds) Food safety in the 21st century. San Diego CA: Academic Press 2017 pp. 491\u2013496 http:\/\/dx.doi.org\/10.1016\/B978-0-12-801773-9.00040-6","DOI":"10.1016\/B978-0-12-801773-9.00040-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061260"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-0850-0"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.11.012"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2016.1208655"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000493840"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-018-1632-2"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122042"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v9.i11.255"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.10.024"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161211795428902"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2018.1469281"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b06025"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2017.09.002"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2015.09.005"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2004.12.002"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.37806"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21300"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1079\/NRR200495"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/437045a"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1526165"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800456"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092039"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v013a06"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(01)00088-1"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4295"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2078::AID-ART358>3.0.CO;2-J"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4133"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep46457"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2010.02547.x"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.12.009"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf505894b"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-010-0476-8"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.12.050"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111640"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113248"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.04.033"},{"issue":"1","key":"e_1_3_3_51_2","first-page":"7","article-title":"Biocatalytic synthesis of flavonoid esters by lipases and their biological benefits","volume":"83","author":"de Araujo ME","year":"2017","unstructured":"de Araujo ME, Franco YE, Messias MC, et al. Biocatalytic synthesis of flavonoid esters by lipases and their biological benefits. Planta Med 2017; 83(1\u20132): 7\u201322.","journal-title":"Planta Med"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12807"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.03.014"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf503357s"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24882"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38774"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key426"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy257"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.08.010"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02794-5"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05567-w"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03038-w"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.10.025"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2017"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05778-1"}],"container-title":["Journal of Tissue Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2041731420922701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2041731420922701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2041731420922701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:27:48Z","timestamp":1777591668000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2041731420922701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":64,"alternative-id":["10.1177\/2041731420922701"],"URL":"https:\/\/doi.org\/10.1177\/2041731420922701","relation":{},"ISSN":["2041-7314","2041-7314"],"issn-type":[{"value":"2041-7314","type":"print"},{"value":"2041-7314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2041731420922701"}}