{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:11:40Z","timestamp":1789117900880,"version":"build-2803163510"},"reference-count":59,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Tissue Eng"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Vascularization remains the rate-limiting factor in biomaterial-based reconstruction of massive mandibular defects. Two distinct strategies have emerged:\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    vascularization through a local blood supply and ectopic prefabrication using the body as an\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    bioreactor before transfer. This first systematic review to directly compare these paradigms, conducted according to a pre-registered protocol (PROSPERO CRD420261368560) and PRISMA 2020. Five databases were searched; risk of bias was assessed with SYRCLE and MINORS, and findings synthesized following the SWiM guideline. Twenty-five studies (16 preclinical, 10 clinical, one both arms) were included. Ectopic prefabrication dominated the corpus (14\/25), with the\n                    <jats:italic toggle=\"yes\">latissimus dorsi<\/jats:italic>\n                    flap the most frequent used bioreactor site. Neither strategy demonstrated clear clinical superiority: the only within-study comparative data favored ectopic prefabrication, but exclusively in non-irradiated preclinical models and at very low certainty of evidence. Across both strategies, bone formation scaled with rhBMP dose irrespective of strategy. This review maps scaffold-strategy interplay and proposes a reporting agenda for next-generation vascularized mandibular constructs.\n                  <\/jats:p>","DOI":"10.1177\/20417314261479038","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:00:26Z","timestamp":1788771626000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>In situ<\/i>\n                    versus ectopic prefabrication strategies for vascularization of bone biomaterials in massive mandibular reconstruction: A systematic review"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1262-5510","authenticated-orcid":false,"given":"Ugo","family":"Lancien","sequence":"first","affiliation":[{"name":"University of Nantes, INSERM, Oniris, CHU Nantes, Regenerative Medicine and 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