{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:24:57Z","timestamp":1786944297841,"version":"build-2736575974"},"reference-count":70,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["PJT 185932"],"award-info":[{"award-number":["PJT 185932"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2018-06290"],"award-info":[{"award-number":["RGPIN-2018-06290"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN 2024-05944"],"award-info":[{"award-number":["RGPIN 2024-05944"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["NSERC RTI-201900310"],"award-info":[{"award-number":["NSERC RTI-201900310"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["NSERC Canada Graduate Research Scholarship \u2013 Master\u2019s Program"],"award-info":[{"award-number":["NSERC Canada Graduate Research Scholarship \u2013 Master\u2019s Program"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031858","name":"Cliff Lede Family Charitable Foundation","doi-asserted-by":"crossref","award":["RES00045921"],"award-info":[{"award-number":["RES00045921"]}],"id":[{"id":"10.13039\/100031858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100019691","name":"Faculty of Medicine and Dentistry, University of Alberta","doi-asserted-by":"publisher","award":["Precision Health Signature Area Innovator Award"],"award-info":[{"award-number":["Precision Health Signature Area Innovator Award"]}],"id":[{"id":"10.13039\/501100019691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Tissue Eng"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Nasoseptal chondrocytes (NCs) are a viable cell source for engineering autologous hyaline cartilage grafts for nasal reconstruction or repairing articular cartilage lesions. Fibroblast growth factor (FGF)-2 and transforming growth factor (TGF)-\u03b21 are commonly used to optimize cell yield and chondrogenic capacity during\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    culture. However, the comprehensive molecular effects of these factors have yet to be elucidated. Leveraging RNA sequencing, this study characterizes the individual and interactive effects of FGF-2 and TGF-\u03b21 on the NC monolayer transcriptome and subsequent 3D cartilage microtissue qualities, revealing that dual-primed NC transcriptomes converge on an FGF-2-like state. Altogether, our analysis of growth factor interactions at the molecular level provides novel, foundational insights into the regulation of intracellular signaling pathways essential to advancing tissue engineering strategies.\n                  <\/jats:p>","DOI":"10.1177\/20417314261479435","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T22:31:02Z","timestamp":1786660262000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["FGF-2 signaling dominance in TGF-\u03b21\/FGF-2\u2013primed nasoseptal chondrocytes for cartilage tissue engineering"],"prefix":"10.1177","volume":"17","author":[{"given":"Zhiyao","family":"Ma","sequence":"first","affiliation":[{"name":"University of Alberta"},{"name":"The First Affiliated Hospital of Shantou University Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5799-7494","authenticated-orcid":false,"given":"Kiarra","family":"Grimes","sequence":"additional","affiliation":[{"name":"University of Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aillette","family":"Mulet-Sierra","sequence":"additional","affiliation":[{"name":"University of Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Kunze","sequence":"additional","affiliation":[{"name":"University of Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4452-2153","authenticated-orcid":false,"given":"Kezhou","family":"Wu","sequence":"additional","affiliation":[{"name":"University of Alberta"},{"name":"The First Affiliated Hospital of Shantou University Medical College"},{"name":"Shantou University"},{"name":"Shantou University Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1798-6251","authenticated-orcid":false,"given":"Adetola B.","family":"Adesida","sequence":"additional","affiliation":[{"name":"University of Alberta"},{"name":"University of Alberta"},{"name":"Shantou University"},{"name":"University of Alberta"},{"name":"University of Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24321"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/1076327041348572"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2010.10.006"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2022.11.022"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/10763270260424178"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60544-4"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31658-0"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ads0848"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00283"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.4103\/REGENMED.REGENMED-D-25-00039"},{"key":"e_1_3_7_12_2","first-page":"e67202","article-title":"Role of Growth Factors in Nasal Cartilage Development and Molding: A Comprehensive Review","volume":"16","author":"Soni N","year":"2024","unstructured":"Soni N, Niranjane P, Purohit A, et al. Role of Growth Factors in Nasal Cartilage Development and Molding: A Comprehensive Review. Cureus 2024; 16: e67202. https:\/\/doi.org\/10.7759\/cureus.67202, Epub ahead of print 19 August 2024.","journal-title":"Cureus"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00178288"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000175541.31131.A5"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4644(20010501)81:2<368::AID-JCB1051>3.0.CO;2-J"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06666-2"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21058"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24418"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2012.0055"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0963689717724794"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.06.016"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.08.011"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.1203"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.153.1.35"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120857"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/bit.24488"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/20417314231172574"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.05.033"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.07.043"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4708"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041580312"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2003.12.021"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807859200"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2011.0670"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-011-9328-5"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.2435"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056983"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609040200"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706508200"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.3.475"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.750047"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2016.03.007"},{"key":"e_1_3_7_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27512"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103547"},{"key":"e_1_3_7_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22001"},{"key":"e_1_3_7_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2451"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.12.008"},{"key":"e_1_3_7_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.02.004"},{"key":"e_1_3_7_49_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201609037"},{"key":"e_1_3_7_50_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7510com"},{"key":"e_1_3_7_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.609653"},{"key":"e_1_3_7_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.23799"},{"key":"e_1_3_7_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56955-1"},{"key":"e_1_3_7_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells14080611"},{"key":"e_1_3_7_55_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e12-03-0172"},{"key":"e_1_3_7_56_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.1213"},{"key":"e_1_3_7_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-012-0080-4"},{"key":"e_1_3_7_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-026-01408-w"},{"key":"e_1_3_7_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells14080611"},{"key":"e_1_3_7_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00583-1"},{"key":"e_1_3_7_61_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.2994"},{"key":"e_1_3_7_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c01675"},{"key":"e_1_3_7_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2018.09.002"},{"key":"e_1_3_7_64_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20260571"},{"key":"e_1_3_7_65_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-087627"},{"key":"e_1_3_7_66_2","doi-asserted-by":"publisher","DOI":"10.1160\/VCOT-06-07-0061"},{"key":"e_1_3_7_67_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.91883.3"},{"key":"e_1_3_7_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78395-y"},{"key":"e_1_3_7_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10865"},{"key":"e_1_3_7_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38849"},{"key":"e_1_3_7_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3185"}],"container-title":["Journal of Tissue Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20417314261479435","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20417314261479435","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20417314261479435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:46:46Z","timestamp":1786942006000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20417314261479435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":70,"alternative-id":["10.1177\/20417314261479435"],"URL":"https:\/\/doi.org\/10.1177\/20417314261479435","relation":{},"ISSN":["2041-7314","2041-7314"],"issn-type":[{"value":"2041-7314","type":"print"},{"value":"2041-7314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"20417314261479435"}}