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It can be used to treat supraventricular and ventricular tachyarrhythmias and has the added advantage of being well tolerated in patients with impaired left ventricular systolic function with a low incidence of arrhythmic events, such as torsades de pointes. However, owing to its marked lipid affinity, it is highly concentrated in tissues and is linked to a number of adverse effects, including thyroid dysfunction. Amiodarone can lead to both hypothyroidism (amiodarone-induced hypothyroidism) and less commonly hyperthyroidism (amiodarone-induced thyrotoxicosis) and relates to high iodine content within the molecule as well as to several unique intrinsic properties of amiodarone. Dronedarone is a recently approved antiarrhythmic drug. It is structurally very similar to amiodarone, however the iodine moiety, present with amiodarone has been removed and replaced with a methylsulfonamide group to reduce fat solubility and adverse effects. We present an overview of the effects of amiodarone on thyroid function and the treatment options available, as well as a brief insight into dronedarone and its potential as an alternative to amiodarone.<\/jats:p>","DOI":"10.1177\/2042018811398516","type":"journal-article","created":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T23:53:48Z","timestamp":1300751628000},"page":"115-126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":74,"title":["Management of amiodarone-related thyroid problems"],"prefix":"10.1177","volume":"2","author":[{"given":"Shashithej K.","family":"Narayana","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Poole Hospital NHS Foundation Trust, Poole, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Woods","sequence":"additional","affiliation":[{"name":"Consultant Physician, Northumbria and Newcastle NHS Trusts, Wansbeck General Hospital and Royal Victoria Infirmary, Honorary Clinical Senior Lecturer, University of Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Boos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Poole Hospital NHS Foundation Trust, Longfleet Road, Poole, Dorset BH15 2JB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,3,21]]},"reference":[{"key":"bibr1-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80098-0"},{"key":"bibr2-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1984.00350150071023"},{"key":"bibr3-2042018811398516","first-page":"423","volume":"78","author":"Bartalena L.","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr4-2042018811398516","first-page":"2930","volume":"81","author":"Bartalena L.","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr5-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.11.028"},{"key":"bibr6-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.04.022"},{"key":"bibr7-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343984"},{"key":"bibr8-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1089\/105072501300176471"},{"key":"bibr9-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1997.7.541"},{"key":"bibr10-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347021"},{"key":"bibr11-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200607000-00007"},{"key":"bibr12-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1002\/pds.735"},{"key":"bibr13-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-32-4-515"},{"key":"bibr14-2042018811398516","first-page":"1062","volume":"102","author":"Brennan M.D.","year":"1987","journal-title":"Surgery"},{"key":"bibr15-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl082"},{"key":"bibr16-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1997.7.177"},{"key":"bibr17-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1210\/endo.134.5.8156930"},{"key":"bibr18-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.225"},{"key":"bibr19-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.054"},{"key":"bibr20-2042018811398516","first-page":"247","volume":"139","author":"Deltour G.","year":"1962","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"bibr21-2042018811398516","doi-asserted-by":"publisher","DOI":"10.1046\/j.0300-0664.2001.01457.x"},{"key":"bibr22-2042018811398516","unstructured":"Food and Drug Administration (2010). 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