{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:50:27Z","timestamp":1790905827311,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Accurate anthropometric measurements and critical analysis of growth data allow the clinician to promptly recognize children with short stature. The aim of this study was to determine the frequency of etiological factors causing short stature among children referred to the pediatric endocrinology clinic of Assiut University Children\u2019s Hospital, the main tertiary care center in Upper Egypt.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted this descriptive observational study from May 2012 to December 2015, to analyze 637 children (boys 354, girls 283) with short stature. Evaluation included: detailed medical history, physical examination, laboratory tests, bone age and chromosomal analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Endocrinological causes accounted for 26% of short stature [of them, 11.8% had growth hormone deficiency (GHD)], 63.6% had normal variants of growth [of them, 42% had familial short stature (FSS), 15.8% had constitutional growth delay (CGD) and 5.5% a combination of both]. Interestingly, celiac disease (CD) constituted 6.6% of children with short stature in our cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although potentially treatable causes such as GHD, hypothyroidism and CD accounted for a considerable percentage of short stature in our study, the majority of short stature in children had normal variations of growth. Growth hormone treatment in children, however, should be promptly initiated with specific clinical indications. CD is a not uncommon cause of short stature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2042018817707464","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T07:52:25Z","timestamp":1493797945000},"page":"75-80","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Etiological factors of short stature in children and adolescents: experience at a tertiary care hospital in Egypt"],"prefix":"10.1177","volume":"8","author":[{"given":"Almontaser","family":"Hussein","sequence":"first","affiliation":[{"name":"Pediatric Department, Faculty of Medicine, Assiut University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hekma","family":"Farghaly","sequence":"additional","affiliation":[{"name":"Pediatric Department, Faculty of Medicine, Assiut University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Askar","sequence":"additional","affiliation":[{"name":"Pediatric Department, Faculty of Medicine, Assiut University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotb","family":"Metwalley","sequence":"additional","affiliation":[{"name":"Pediatric Department, Faculty of Medicine, Assiut University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Saad","sequence":"additional","affiliation":[{"name":"Associate Professor of Pediatrics, Faculty of Medicine, University of Assiut, Assiut 71516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Zahran","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham A.","family":"Othman","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Aswan University, Aswan, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"bibr1-2042018817707464","doi-asserted-by":"publisher","DOI":"10.1177\/0009922806290597"},{"key":"bibr2-2042018817707464","doi-asserted-by":"publisher","DOI":"10.1007\/BF02760701"},{"key":"bibr3-2042018817707464","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-014-1609-y"},{"key":"bibr4-2042018817707464","doi-asserted-by":"publisher","DOI":"10.1542\/pir.26-11-410"},{"key":"bibr5-2042018817707464","doi-asserted-by":"publisher","DOI":"10.1007\/BF02723154"},{"key":"bibr6-2042018817707464","first-page":"493","volume":"18","author":"Sultan M","year":"2008","journal-title":"J Coll Physicians Surg 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