{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:17:45Z","timestamp":1777879065328,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aims to assess the levels of visfatin in children and adolescents with autoimmune thyroiditis (AIT) and its relationship with disease-related variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 84 children and adolescents with AIT and 84 healthy subjects. Measurements of fasting glucose, insulin, thyroid-stimulating hormone (TSH), free thyroxin (FT4), antithyroid peroxidase antibodies (TPOAb) and antithyroglobulin antibody (TgAb) were completed, with assessment of visfatin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overt hypothyroidism was diagnosed in 58 cases, while subclinical hypothyroidism was diagnosed in 26 of the studied patients. Total studied cases, overt and subclinical subgroups had significantly higher levels of TSH, HOMA-IR, TPOAb, TgAb and visfatin and significantly lower FT4 level compared with the control. Spearman correlation analysis revealed that visfatin was correlated positively with BMI, homeostasis model assessment (HOMA-IR), TSH and TPOAb, while inversely correlation with FT4. In logistic regression analysis, visfatin was correlated only with TPOAb.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This preliminary study provides evidence of significantly higher level of visfatin in children and adolescents with AIT. Visfatin might have a potential role in the pathogenesis of AIT, which needs to be validated by measuring immunological responses in children and adolescents with AIT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2042018817731073","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T10:55:45Z","timestamp":1506336945000},"page":"119-125","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Visfatin level in children and adolescents with autoimmune thyroiditis"],"prefix":"10.1177","volume":"8","author":[{"given":"Hekma Saad","family":"Farghaly","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotb Abbass","family":"Metwalley","sequence":"additional","affiliation":[{"name":"Professor of Pediatrics, Pediatric Endocrinology Unit, Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal-Alkhateeb","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duaa Mohamed","family":"Raafat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama","family":"El-Asheer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Mahmood","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahlam","family":"Bahdawy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa Mohamed","family":"Zahran","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"key":"bibr1-2042018817731073","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199402173300704"},{"key":"bibr2-2042018817731073","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1995.5.117"},{"key":"bibr3-2042018817731073","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.04.004"},{"key":"bibr4-2042018817731073","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0208"},{"key":"bibr5-2042018817731073","doi-asserted-by":"publisher","DOI":"10.1530\/EC-13-0061"},{"key":"bibr6-2042018817731073","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7402469"},{"key":"bibr7-2042018817731073","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03546.x"},{"key":"bibr8-2042018817731073","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346482"},{"key":"bibr9-2042018817731073","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870140208"},{"key":"bibr10-2042018817731073","unstructured":"Diabetes Endocrine Metabolism Pediatric Unit, Cairo University Children\u2019s Hospital. 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