{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:17:58Z","timestamp":1777879078978,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T00:00:00Z","timestamp":1527984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Information is inconsistent regarding the clinical role of acute elevations of blood glucose level secondary to hospital-acquired infections in nondiabetic critically ill patients during an intensive care unit stay. In this study we investigated the clinical significance of hyperglycemia related to new episodes of ventilator-associated pneumonia in nondiabetic critically ill multiple trauma intensive care unit patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We analyzed the clinical data of 202 critically ill multiple trauma patients with no history of previous diabetes who developed a new ventilator-associated pneumonia episode during their intensive care unit stay. We used a time-from-event analysis method to assess whether acute changes in blood glucose levels that occurred prior to the onset of ventilator-associated pneumonia episodes had a different prognostic significance from those that occurred during such episodes. Glucose levels and other laboratory data were recorded for up to 5 days before ventilator-associated pneumonia events and for 5 days following these events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients who required insulin therapy for persistent hyperglycemia related to a new ventilator-associated pneumonia event had a longer period of intensive care unit stay and a higher intensive care unit mortality rate than patients who did not require insulin for blood glucose control ( p &lt; 0.008 and &lt;0.001 respectively). In addition, older age, administration of parenteral nutrition, and elevated mean blood glucose level parameters on the day following the day of diagnosis of a new ventilator-associated pneumonia episode were found to be independent risk factors for intensive care unit mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study suggests that persistent hyperglycemia in nondiabetic critically ill patients, even treated by early insulin therapy, is an adverse prognostic factor of considerable clinical significance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2042018818779746","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T02:28:56Z","timestamp":1528079336000},"page":"223-230","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The clinical significance of hyperglycemia in nondiabetic critically ill multiple trauma patients"],"prefix":"10.1177","volume":"9","author":[{"given":"Leonid","family":"Koyfman","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeni","family":"Brotfain","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Soroka Medical Center, Ben-Gurion University of the Negev, Sderot Rager 47, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoav","family":"Bichovsky","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Kovalenko","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yair","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Borer","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Friger","sequence":"additional","affiliation":[{"name":"Health Science Faculty, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moti","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,6,3]]},"reference":[{"key":"bibr1-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011300"},{"key":"bibr2-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000201408.15502.24"},{"key":"bibr3-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810625"},{"key":"bibr4-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.179"},{"key":"bibr5-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e31825d60e5"},{"key":"bibr6-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1177\/000313480507100215"},{"key":"bibr7-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181f4e499"},{"key":"bibr8-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2011.06.011"},{"key":"bibr9-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1186\/cc8804"},{"key":"bibr10-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181810378"},{"key":"bibr11-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1016\/0196-6553(88)90053-3"},{"key":"bibr12-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2011.01.003"},{"key":"bibr13-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.15.2041"},{"key":"bibr14-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182653269"},{"key":"bibr15-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2013.164"},{"key":"bibr16-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000123267.39011.9F"},{"key":"bibr17-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000162141.26392.07"},{"key":"bibr18-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1186\/cc11657"},{"key":"bibr19-2042018818779746","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001683"}],"container-title":["Therapeutic 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