{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:17:55Z","timestamp":1777879075169,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Individuals with PTEN Hamartoma Tumor Syndrome (PHTS) are at greatly increased risk for developing well-differentiated thyroid cancer. Specific circumstances in which total thyroidectomies should be considered have not been defined. A 14-year-old macrocephalic female with history of developmental delay and lipoma over her left flank presented with neck swelling and was found have multinodular goiter and auto-immune thyroiditis. Asymptomatic tracheal narrowing was also detected on her initial diagnostic imaging. Later on, she developed positional dyspnea during sleep. Genetic testing revealed a heterozygous pathogenic variant in the PTEN gene (c.463T&gt;A). A total thyroidectomy was performed. In addition to addressing the symptomology in our case, a total thyroidectomy also fortuitously eliminated the thyroid cancer risk. This case spurred us on further to identify specific clinical scenarios where total thyroidectomy may be considered as a true prophylactic measure to manage thyroid cancer risk in PHTS patients.<\/jats:p>","DOI":"10.1177\/2042018818784517","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T06:44:40Z","timestamp":1530686680000},"page":"299-301","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Considerations for total thyroidectomy in an adolescent with\n                    <i>PTEN<\/i>\n                    mutation"],"prefix":"10.1177","volume":"9","author":[{"given":"Mustafa","family":"Tosur","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Diabetes and Endocrinology, Texas Children\u2019s Hospital, Baylor College of Medicine, 6701 Fannin Street, Ste 10.20, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary L.","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Surgery, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna D.","family":"Athanassaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surya P.","family":"Rednam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"bibr1-2042018818784517","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.08.055"},{"key":"bibr2-2042018818784517","unstructured":"National Cancer Institute.\n                      Cancer stat facts: thyroid cancer\n                      . Surveillance, Epidemiology and End Results Program, 2018. https:\/\/seer.cancer.gov\/statfacts\/html\/thyro.html (accessed on 22 June 2018)"},{"key":"bibr3-2042018818784517","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-305997"},{"key":"bibr4-2042018818784517","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1315"},{"key":"bibr5-2042018818784517","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1616"},{"key":"bibr6-2042018818784517","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2283"},{"key":"bibr7-2042018818784517","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0003"},{"key":"bibr8-2042018818784517","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(99)80011-2"},{"key":"bibr9-2042018818784517","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0629"}],"container-title":["Therapeutic Advances in Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2042018818784517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2042018818784517","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2042018818784517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:34:34Z","timestamp":1777592074000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2042018818784517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,4]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1177\/2042018818784517"],"URL":"https:\/\/doi.org\/10.1177\/2042018818784517","relation":{},"ISSN":["2042-0188","2042-0196"],"issn-type":[{"value":"2042-0188","type":"print"},{"value":"2042-0196","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,4]]}}}