{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:34:53Z","timestamp":1787510093286,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Zwols Wetenschapsfonds Isala Klinieken","award":["Not applicable."],"award-info":[{"award-number":["Not applicable."]}]},{"name":"Isala Innovatie and Wetenschapsfonds","award":["INNO1717"],"award-info":[{"award-number":["INNO1717"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Type 1 diabetes mellitus (T1DM) is associated with inflammation and the production of reactive oxygen species (ROS). Systemically, free thiols (R-SH) can be oxidized by ROS and circulating R-SH concentrations may directly reflect the systemic redox status. In this study the association between R-SH and clinical parameters of T1DM, including glycated haemoglobin A1c (HbA1c), was investigated. This is of particular interest since thiols are amendable to therapeutic intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>As part of a prospective cohort study, data from 216 patients with a mean age of 45 (12) years, 57% male, diabetes duration 22 (16, 30) years and HbA1c of 60 (11) mmol\/mol were examined. Baseline data were collected in 2002 and follow-up data in 2018. Cox proportional hazards regression analysis, with age, sex, HbA1c and R-SH, was used to assess prognostic factors for the development of complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At baseline, the plasma concentration of R-SH was 281.8\u2009\u00b1\u200934.0\u2009\u03bcM. In addition to a lower concentration of NT-proBNP in the highest R-SH quartile (305\u2013379\u2009\u00b5M) there were no differences in baseline characteristics between the quartiles of R-SH. The Pearson correlation coefficient for R-SH and NT-proBNP was \u22120.290 ( p\u2009&lt;\u20090.001). No significant correlation between R-SH and baseline HbA1c ( r\u2009=\u2009\u22120.024, p\u2009=\u20090.726) was present. During follow-up, 42 macrovascular and 92 microvascular complications occurred. In Cox regression, R-SH was not a prognostic factor for the development of microvascular [hazard ratio (HR) 0.999 (95% confidence interval (CI) 0.993, 1.005)] and macrovascular [HR 0.993 (95% CI 0.984, 1.002)] complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In addition to a negative association with NT-proBNP, no relevant relationships between R-SH and parameters of T1DM, including HbA1c, were present in this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2042018820903641","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T08:30:02Z","timestamp":1581064202000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Thiols as markers of redox status in type 1 diabetes mellitus"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9702-6551","authenticated-orcid":false,"given":"Peter R.","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Groningen, University Medical Center, Hanzeplein 1, 9700 RB, HP AA41, Groningen, The Netherlands"},{"name":"Isala, Diabetes Centre, Zwolle, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pasch","sequence":"additional","affiliation":[{"name":"Calciscon AG, Nidau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja L.","family":"van Ockenburg-Brunet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Groningen, University Medical Center, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke","family":"Waanders","sequence":"additional","affiliation":[{"name":"Isala, Department of Internal Medicine, Zwolle, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Eman Abdulle","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, University of Groningen, University Medical Center, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian J.","family":"Muis","sequence":"additional","affiliation":[{"name":"Isala, Diabetes Centre, Zwolle, the Netherlands"},{"name":"Isala, Department of Internal Medicine, Zwolle, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Hillebrands","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk J. G.","family":"Bilo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Groningen, University Medical Center, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"bibr1-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.01.002"},{"key":"bibr2-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2014.05.017"},{"key":"bibr3-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2015.03.013"},{"key":"bibr4-2042018820903641","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"bibr5-2042018820903641","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1720"},{"key":"bibr6-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.2.653S"},{"key":"bibr7-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.05.050"},{"key":"bibr8-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2013.07.005"},{"key":"bibr9-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.06.027"},{"key":"bibr10-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(02)00175-4"},{"key":"bibr11-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2007.04.005"},{"key":"bibr12-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1089\/109454503323028920"},{"key":"bibr13-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2015.06.016"},{"key":"bibr14-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.08.024"},{"key":"bibr15-2042018820903641","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8090351"},{"key":"bibr16-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0784-6"},{"key":"bibr17-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026197119569"},{"key":"bibr18-2042018820903641","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i4.569"},{"key":"bibr19-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"bibr20-2042018820903641","first-page":"257","volume":"121","author":"Hu ML","year":"1993","journal-title":"J Lab Clin Med"},{"key":"bibr21-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.10.001"},{"key":"bibr22-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv305"},{"key":"bibr23-2042018820903641","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00292-2"}],"container-title":["Therapeutic Advances in Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2042018820903641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2042018820903641","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2042018820903641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:34:59Z","timestamp":1777592099000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2042018820903641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":23,"alternative-id":["10.1177\/2042018820903641"],"URL":"https:\/\/doi.org\/10.1177\/2042018820903641","relation":{},"ISSN":["2042-0188","2042-0196"],"issn-type":[{"value":"2042-0188","type":"print"},{"value":"2042-0196","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2042018820903641"}}