{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:55:00Z","timestamp":1790567700897,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"\n Background:<\/jats:title>\n Hashimoto\u2019s thyroiditis (HT) is a common autoimmune disorder that causes significant morbidity. Interleukin (IL)-17 was identified as a major contributing factor in the pathogenesis of HT. Blastocystis hominis (BH) is a very common infection and has been shown to be associated with several diseases. Our aim was to determine serum IL-17 level in HT patients with and without BH infection and the effect of eradicating BH in patients with HT.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A prospective cohort study was conducted on 20 HT patients not infected with BH (group I), 20 HT patients infected with BH (group II), and 20 healthy patients (group III). Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroid peroxidase antibodies (anti-TPO), and IL-17 were performed by ELISA method and were repeated in group II after 6\u2009weeks of eradication of BH.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Patients with HT showed a significantly higher serum IL-17 compared with controls. IL-17 was significantly higher in HT patients infected with BH compared with HT patients not BH infected (mean 6.93\u2009\u00b1\u20092.83\u2009pg\/ml versus 3.25\u2009\u00b1\u20091.55\u2009pg\/ml, p\u2009=\u20090.003). After BH eradication TSH, anti-TPO, and IL-17 were significantly decreased (mean 14.76\u2009\u00b1\u200911.11\u2009\u00b5IU\/ml versus 9.39\u2009\u00b1\u20097.11\u2009\u00b5IU\/ml, p\u2009<\u20090.001; mean 308\u2009\u00b1\u2009175.6\u2009IU\/ml versus 295.4\u2009\u00b1\u2009167.1\u2009IU\/ml, p\u2009=\u20090.006; and mean 6.93\u2009\u00b1\u20092.83\u2009pg\/ml versus 6.45\u2009\u00b1\u20092.48\u2009pg\/ml, p\u2009<\u20090.001), respectively. Multivariate analysis after treating BH infection showed that IL-17 was significantly negatively correlated with FT3 (adjusted p\u2009=\u20090.002) and significantly positively correlated with anti-TPO (adjusted p\u2009=\u20090.045).<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Treatment of BH infection ameliorates HT through reduction in IL-17, anti-TPO, and TSH.<\/jats:p>\n <\/jats:sec>\n \n Clinical trial registration number:<\/jats:title>\n PACTR201909495111649<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/2042018820907013","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T07:42:35Z","timestamp":1582270955000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Improving Hashimoto\u2019s thyroiditis by eradicating\n Blastocystis hominis<\/i>\n : Relation to IL-17"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-7689","authenticated-orcid":false,"given":"Hanaa Tarek","family":"El-Zawawy","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Endocrinology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda Fahmy","family":"Farag","sequence":"additional","affiliation":[{"name":"Applied and Molecular Parasitology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona Mohamed","family":"Tolba","sequence":"additional","affiliation":[{"name":"Applied and Molecular Parasitology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa Abdalbasit","family":"Abdalsamea","sequence":"additional","affiliation":[{"name":"Applied and Molecular Parasitology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"key":"bibr1-2042018820907013","first-page":"51","volume":"20","author":"Liontiris MI","year":"2017","journal-title":"Hell J Nucl Med"},{"key":"bibr2-2042018820907013","doi-asserted-by":"publisher","DOI":"10.2174\/138920211798120763"},{"key":"bibr3-2042018820907013","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.1827"},{"key":"bibr4-2042018820907013","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.IJEM_412_16"},{"key":"bibr5-2042018820907013","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2019009"},{"key":"bibr6-2042018820907013","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.02.011"},{"key":"bibr7-2042018820907013","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.10.001"},{"key":"bibr8-2042018820907013","doi-asserted-by":"publisher","DOI":"10.2149\/tmh.2013-23"},{"key":"bibr9-2042018820907013","unstructured":"Blastocystis sp. https:\/\/www.cdc.gov\/dpdx\/blastocystis\/index.html."},{"key":"bibr10-2042018820907013","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02279-14"},{"key":"bibr11-2042018820907013","doi-asserted-by":"publisher","DOI":"10.1007\/s004360100494"},{"key":"bibr12-2042018820907013","first-page":"676","volume":"24","author":"Wu LY","year":"2012","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"bibr13-2042018820907013","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(01)00191-7"},{"key":"bibr14-2042018820907013","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.4851"},{"key":"bibr15-2042018820907013","first-page":"353","volume":"3","author":"Altamemi IA","year":"2017","journal-title":"World J Pharm Med Res"},{"key":"bibr16-2042018820907013","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06137"},{"key":"bibr17-2042018820907013","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6757154"},{"key":"bibr18-2042018820907013","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6614-6-S2-A8"},{"key":"bibr19-2042018820907013","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2019.74"}],"container-title":["Therapeutic Advances in Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2042018820907013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2042018820907013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2042018820907013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:35:01Z","timestamp":1777592101000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2042018820907013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":19,"alternative-id":["10.1177\/2042018820907013"],"URL":"https:\/\/doi.org\/10.1177\/2042018820907013","relation":{},"ISSN":["2042-0188","2042-0196"],"issn-type":[{"value":"2042-0188","type":"print"},{"value":"2042-0196","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2042018820907013"}}