{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:18:14Z","timestamp":1777879094743,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Serum calcification propensity can be monitored using the maturation time of calciprotein particles in serum (T\n                      <jats:sub>50<\/jats:sub>\n                      test). A shorter T\n                      <jats:sub>50<\/jats:sub>\n                      indicates greater propensity to calcify; this is an independent determinant of cardiovascular disease. As the intraperitoneal (IP) route of insulin administration mimics the physiology more than the subcutaneous (SC) route in persons with type 1 diabetes (T1DM), we hypothesized that IP insulin influences determinants of calcium propensity and therefore result in a longer T\n                      <jats:sub>50<\/jats:sub>\n                      than SC insulin administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective, observational case-control study. Measurements were performed at baseline and at 26\u2009weeks in age and gender matched persons with T1DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 181\u2009persons, 39 (21.5%) of which used IP and 142 (78.5%) SC insulin were analysed. Baseline T\n                      <jats:sub>50<\/jats:sub>\n                      was 356 (45) minutes. The geometric mean T\n                      <jats:sub>50<\/jats:sub>\n                      significantly differed between both treatment groups: 367 [95% confidence interval (CI) 357, 376] for the IP group and 352 (95% CI 347, 357) for the SC group with a difference of \u201315 (95% CI \u201325, \u20134) minutes, in favour of IP treatment. In multivariable analyses, the IP route of insulin administration had a positive relation on T\n                      <jats:sub>50<\/jats:sub>\n                      concentrations while higher age, triglycerides and phosphate concentrations had an inverse relation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Among persons with T1DM, IP insulin administration results in a more favourable calcification propensity time then SC insulin. It has yet to be shown if this observation translates into improved cardiovascular outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2042018820908456","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T05:18:26Z","timestamp":1583212706000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9702-6551","authenticated-orcid":false,"given":"Peter R.","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Groningen, 9713 GZ, HPA AA41, Groningen, The Netherlands"},{"name":"Isala, Diabetes Centre, Zwolle, The Netherlands"},{"name":"Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke","family":"Waanders","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Isala, Zwolle, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Pasch","sequence":"additional","affiliation":[{"name":"Calciscon AG, Nidau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan J. 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