{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:00:10Z","timestamp":1792652410342,"version":"4.5.0"},"reference-count":76,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The study received statutory funding from the Jerzy Kukuczka Academy of Physical Education, Katowice, Poland, no additional funding was received."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aimed to determine the effect of moderate intensity continuous exercise (Ex) and hypoxia (Hyp) on serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3), irisin and cytokines levels in patients with type\u20091 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 14 individuals with T1D (age: 28.7\u2009\u00b1\u20097.3\u2009years) and 14 healthy adults (age: 27.1\u2009\u00b1\u20093.9\u2009years) performed 40-min continuous Ex at moderate intensity (50% lactate threshold) on a cycle ergometer in normoxia (Nor) and Hyp (FiO\n                      <jats:sub>2<\/jats:sub>\n                      \u2009=\u200915.1%) Biochemical factors, glucose concentrations and physiological variables were measured at rest, immediately and up to 24\u2009h after both Ex protocols.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients with T1D had significantly lower pre-Ex serum concentrations of BDNF ( p\u2009&lt;\u20090.05, p\u2009&lt;\u20090.01), and total IGF-1 ( p\u2009&lt;\u20090.001, p\u2009&lt;\u20090.05) and significantly higher irisin levels ( p\u2009&lt;\u20090.05, p\u2009&lt;\u20090.01) in Nor and Hyp, compared with healthy subjects. Ex significantly increased in T1D group serum BDNF (in Nor only p\u2009&lt;\u20090.05) and total IGF-1 levels in Nor and Hyp ( p\u2009&lt;\u20090.001 and p\u2009&lt;\u20090.01, respectively). Immediately after Ex in Hyp, freeIGF-1 ( p\u2009&lt;\u20090.05) and irisin levels ( p\u2009&lt;\u20090.001) were significantly higher compared with the levels induced by Ex alone. Free IGF-1 and irisin serum levels remained elevated in 24\u2009h post-Ex in Hyp. In T1D, significant blood glucose (BG) decrease was observed immediately after Ex in Hyp ( p\u2009&lt;\u20090.001) and in 24\u2009h recovery ( p\u2009&lt;\u20090.001) compared with pre-Ex level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The study results suggest that moderate intensity continuous Ex has beneficial effect on BDNF and IGF-1 levels. Ex in hypoxic conditions may be more effective in increasing availability of IGF-1. The alterations in the post-Ex irisin levels and IGF-1 system may be contributing to more effective glycaemia control in patients with T1D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2042018820925326","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T08:06:48Z","timestamp":1590566808000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Moderate intensity exercise in hypoxia increases IGF-1 bioavailability and serum irisin in individuals with type 1 diabetes"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7446-528X","authenticated-orcid":false,"given":"Aleksandra","family":"\u017bebrowska","sequence":"first","affiliation":[{"name":"Institute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education, Mikolowska Street 72 A, Katowice 40-065, 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