{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:18:26Z","timestamp":1777879106931,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Beijing Municipal Administration of Hospitals Incubating Program","award":["PX2017013"],"award-info":[{"award-number":["PX2017013"]}]},{"DOI":"10.13039\/501100009331","name":"beijing municipal administration of hospitals clinical medicine development of special funding support","doi-asserted-by":"publisher","award":["ZYLX201824"],"award-info":[{"award-number":["ZYLX201824"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Low serum parathyroid hormone (PTH) level and secondary hyperparathyroidism (SHPT) are very common in hemodialysis patients. However, the outcomes of patients with low PTH level or SHPT have not been carefully compared. Therefore, in the present study, we compared the outcomes of hemodialysis patients with low PTH level or SHPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a multi-center, prospective, cohort study of 647 patients. The patients were recruited between 1 September 2016 and 1 January 2017 and followed until 31 December 2018. The participants were allocated to a low PTH group [serum intact PTH (iPTH) concentration\u2009&lt;\u200960\u2009pg\/ml] and an SHPT group (iPTH\u2009\u2a7e\u2009600\u2009pg\/ml) according to their mean iPTH concentration across the entire observation period, and the outcomes were compared between these groups. The primary outcome was a composite outcome, which comprised all-cause mortality, non-fatal acute myocardial infarction, non-fatal acute stroke, and acute heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 197 hemodialysis patients were allocated to the two groups: 87 with low PTH level and 110 with SHPT; 450 patients with time-averaged iPTH concentrations of 60\u2013600\u2009pg\/ml were excluded. Kaplan\u2013Meier analysis of the composite endpoint revealed a significant difference between participants with low PTH level and those with SHPT ( p\u2009=\u20090.002). Cox multiple regression showed that participants with low PTH level had a higher incidence of the composite endpoint than those with SHPT (relative risk: 1.337, 95% confidence interval: 1.059\u20131.688).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Hemodialysis patients with low PTH level had a higher incidence of mortality and non-fatal cardiovascular events than those with SHPT, irrespective of whether the participants were age-matched.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2042018820958322","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T01:54:12Z","timestamp":1600739652000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Hemodialysis patients with low serum parathyroid hormone levels have a poorer prognosis than those with secondary hyperparathyroidism"],"prefix":"10.1177","volume":"11","author":[{"given":"Yue","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"},{"name":"Department of Nephrology, Fu Xing Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongli","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, 95 Yong\u2019An Road, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fu Xing Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology, People\u2019s Hospital of Beijing Daxing District, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Hospital of Shunyi District Beijing, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6532-4394","authenticated-orcid":false,"given":"Wenhu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, 95 Yong\u2019An Road, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"bibr1-2042018820958322","first-page":"102","volume":"60","author":"Jeloka T","year":"2017","journal-title":"J Assoc Physicians 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