{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:01:01Z","timestamp":1791414061736,"version":"4.3.3"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Isala innovatie en wetenschapsfonds","award":["INNO1717"],"award-info":[{"award-number":["INNO1717"]}]},{"name":"Zwols Wetenschapsfonds Isala Klinieken"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Among persons with type 1 diabetes mellitus (T1DM) low concentrations of magnesium have been reported. Previous (small) studies also suggested a relation of hypomagnesemia with (poor) glycaemic control and complications. We aimed to investigate the magnitude of hypomagnesemia and the associations between magnesium with parameters of routine T1DM care in a population of unselected outpatients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>As part of a prospective cohort study, initially designed to measure quality of life and oxidative stress, data from 207 patients with a mean age of 45 [standard deviation (SD) 12] years, 58% male, diabetes duration 22 [interquartile range (IQR) 16, 31] years and glycated haemoglobin (HbA1c) of 60 (SD 11) mmol\/mol [7.6 (SD 1.0)%] were examined. Hypomagnesemia was defined as a concentration below &lt;0.7\u2009mmol\/l.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean magnesium concentration was 0.78 (SD 0.05) mmol\/l. A deficiency was present in 4.3% of participants. Among these persons, mean concentration was 0.66 (SD 0.03) mmol\/l. There was no correlation between magnesium and HbA1c at baseline ( r\u2009=\u2009\u20130.014, p\u2009=\u20090.843). In multivariable analysis, free thiols (reflecting the degree of oxidative stress) were significantly and negatively associated with magnesium concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this cohort of T1DM outpatients, the presence of hypomagnesemia was infrequent and, if present, relative mild. Magnesium was not associated with glycaemic control nor with presence of micro- and macrovascular complications. Although these results need confirmation, in particular the negative association of magnesium with free thiols, this suggests that hypomagnesemia is not a relevant topic in routine care for people with T1DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2042018820980240","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T05:31:08Z","timestamp":1609219868000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Hypomagnesemia in persons with type 1 diabetes: associations with clinical parameters and oxidative stress"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9702-6551","authenticated-orcid":false,"given":"Peter R.","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Endocrinology, University Medical Center, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Waanders","sequence":"additional","affiliation":[{"name":"Isala, Department of Internal Medicine, Zwolle, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiedong","family":"Qiu","sequence":"additional","affiliation":[{"name":"5th Medical Department, Universit\u00e4tsklinikum Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah H. R.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Groningen, University Medical Center, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"van Goor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J. G.","family":"Bilo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Groningen, University Medical Center, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"bibr1-2042018820980240","first-page":"47","volume":"24","author":"Swaminathan R","year":"2003","journal-title":"Clin Biochem Rev"},{"key":"bibr2-2042018820980240","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S42054"},{"key":"bibr3-2042018820980240","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02960906"},{"key":"bibr4-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02116-3"},{"key":"bibr5-2042018820980240","first-page":"193","volume":"5","author":"Garland HO","year":"1992","journal-title":"Magnes Res"},{"key":"bibr6-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-10-4"},{"key":"bibr7-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.06.019"},{"key":"bibr8-2042018820980240","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.4.1147"},{"key":"bibr9-2042018820980240","doi-asserted-by":"crossref","unstructured":"American Diabetes Association. Effect of Mg2+ on Na+-dependent inositol transport: role for Mg2+ in etiology of diabetic complications. Diabetes, https:\/\/diabetes.diabetesjournals.org\/content\/41\/1\/35 (accessed 4 March 2020).","DOI":"10.2337\/diabetes.41.1.35"},{"key":"bibr10-2042018820980240","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.103020"},{"key":"bibr11-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.01.015"},{"key":"bibr12-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026197119569"},{"key":"bibr13-2042018820980240","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i4.569"},{"key":"bibr14-2042018820980240","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1028"},{"key":"bibr15-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0517"},{"key":"bibr16-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7083"},{"key":"bibr17-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.06.027"},{"key":"bibr18-2042018820980240","volume":"16","author":"Schillern EEM","year":"2019","journal-title":"J Clin Transl Endocrinol"},{"key":"bibr19-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1177\/2042018820903641"},{"key":"bibr20-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400735"},{"key":"bibr21-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1982.tb00942.x"},{"key":"bibr22-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12118"},{"key":"bibr23-2042018820980240","doi-asserted-by":"publisher","DOI":"10.7603\/s40681-016-0020-6"},{"key":"bibr24-2042018820980240","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.14.11.1050"},{"key":"bibr25-2042018820980240","first-page":"539","volume":"23","author":"Zargar AH","year":"2002","journal-title":"Saudi Med J"},{"key":"bibr26-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1016\/S0946-672X(97)80044-2"},{"key":"bibr27-2042018820980240","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.3.294"}],"container-title":["Therapeutic Advances in Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2042018820980240","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2042018820980240","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2042018820980240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:35:29Z","timestamp":1777592129000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2042018820980240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":27,"alternative-id":["10.1177\/2042018820980240"],"URL":"https:\/\/doi.org\/10.1177\/2042018820980240","relation":{},"ISSN":["2042-0188","2042-0196"],"issn-type":[{"value":"2042-0188","type":"print"},{"value":"2042-0196","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2042018820980240"}}