{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:45:52Z","timestamp":1789400752605,"version":"build-2803163510"},"reference-count":68,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Charcot foot is a severe complication of diabetes mellitus. Amputation is associated with 5-year mortality rates as high as 70%, and the overall treatment cost for diabetic foot surpasses that of conditions such as cancer or depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare clinical, quality-of-life, and cost outcomes related to Charcot foot management through two distinct treatments: amputation and resection with stabilization using circular external fixation (CEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study included all adult patients treated at our unit between 2008 and 2022 for acute diabetic foot with infected ulcers. The allocation to treatment groups was based on the timing of patient enrollment. We gathered anthropometric, diagnostic, and surgical data, documenting individualized costs for preoperative, postoperative, and rehabilitation phases. Health status was assessed using the EQ-5D-3L questionnaire, and recorded data included mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 31 patients (18 amputations; 13 CEF) were included. Amputees exhibited significantly higher mortality compared to those with a CEF (44.8% vs 7.7%, p\u2009=\u20090.045). The estimated 3-year survival was 60.8% for amputees and 90% for the CEF group (log-rank test, p\u2009=\u20090.096). In terms of quality of life (EQ-5D-3L), amputees reported a reduction of 14.67 points while CEF patients reported an increase of 40.39 points ( p\u2009&lt;\u20090.001). The EQ-5D-3L index improved by 1.8 points for amputees, as compared with 62.3 points in the CEF group ( p\u2009&lt;\u20090.001). The total mean cost of managing an amputated patient was \u20ac222,864, practically identical to the \u20ac224,438 incurred in the CEF group ( p\u2009=\u20090.767). No statistically significant differences were found in the time distribution of costs. However, some specific expense items demonstrated statistical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In treating infected diabetic foot ulcers, external fixation leads to a better quality of life compared to amputation. There\u2019s also a trend suggesting higher survival rates with external fixation, and both approaches have similar costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420188241271795","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T08:38:59Z","timestamp":1728376739000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Amputation versus circular external fixation in the treatment of diabetic foot with osteomyelitis: a cost and quality-of-life analysis"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1204-900X","authenticated-orcid":false,"given":"Laia","family":"L\u00f3pez Capdevilla","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Hospital de la Santa Creu i Sant Pau, Carrer de Sant Quint\u00ed, 89, Barcelona 08025, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Santamar\u00eda Fumas","sequence":"additional","affiliation":[{"name":"Consorci Sanitari Integral, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Sales P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Consorci Sanitari Integral, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Dom\u00ednguez Sevilla","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Consorci Sanitari Integral, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"del Corral Cuervo","sequence":"additional","affiliation":[{"name":"Department of Economic Analysis and Finance, University of Castilla\u2013La Mancha, Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Varela-Quintana","sequence":"additional","affiliation":[{"name":"Department of Applied Economics, University of Oviedo, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Rabanal Rubio","sequence":"additional","affiliation":[{"name":"MBA Institute, Gij\u00f3n, Spain"},{"name":"C\u00e1tedra MBA Institute de Investigaci\u00f3n M\u00e9dica y Biomec\u00e1nica. University of Oviedo, Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Roza Miguel","sequence":"additional","affiliation":[{"name":"MBA Institute, Gij\u00f3n, Spain"},{"name":"C\u00e1tedra MBA Institute de Investigaci\u00f3n M\u00e9dica y Biomec\u00e1nica, University of Oviedo, Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"bibr1-20420188241271795","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"bibr2-20420188241271795","doi-asserted-by":"publisher","DOI":"10.1016\/S1067-2516(07)60001-5"},{"key":"bibr3-20420188241271795","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B9.37038"},{"key":"bibr4-20420188241271795","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3165"},{"key":"bibr5-20420188241271795","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B9.37038"},{"key":"bibr6-20420188241271795","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2750"},{"key":"bibr7-20420188241271795","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2018.09.013"},{"key":"bibr8-20420188241271795","unstructured":"World Health Organization. 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