{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:19:23Z","timestamp":1777879163484,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\u2022\u2003Children with growth hormone deficiency (GHD) are often prescribed a growth hormone called somatropin to help them grow.<\/jats:p>\n                  <jats:p>\u2022\u2003As prescribed, somatropin needs to be injected once a day under the skin. Some children may miss many of their somatropin injections, and this is known as having \u201clow adherence\u201d to treatment. Adherence in this study refers to whether the children had enough somatropin to have daily injections as prescribed.<\/jats:p>\n                  <jats:p>\u2022\u2003In this study, researchers found that children with GHD who had high adherence to daily somatropin injections grew more than children who had low adherence to daily somatropin injections.<\/jats:p>\n                  <jats:p>\u2022\u2003Researchers, doctors, and nurses need to look at how they can help children with GHD follow their prescribed injection schedule and reduce the number of missed injections.<\/jats:p>\n                  <jats:p>The purpose of this plain language summary is to help you to understand the findings from recent research.<\/jats:p>\n                  <jats:p>\u2022\u2003Somatropin is approved to treat the condition under study that is discussed in this summary.<\/jats:p>\n                  <jats:p>\u2022\u2003This summary reports the results of a single study. The results of this study may differ from those of other studies. Health professionals should make treatment decisions based on all available evidence, not on the results of a single study.<\/jats:p>\n                  <jats:p>Glossary of commonly used terms<\/jats:p>\n                  <jats:p>Adherence \u2013 in this study, adherence refers to whether the children had enough medication (somatropin) to have daily injections as prescribed by their doctor.<\/jats:p>\n                  <jats:p>Growth hormone - a protein made in the pituitary gland that helps the body grow properly.<\/jats:p>\n                  <jats:p>Growth hormone deficiency \u2013 children with this condition do not have enough growth hormone in their bodies so they grow more slowly than children with normal levels of growth hormone.<\/jats:p>\n                  <jats:p>Somatropin - a type of human growth hormone that can be made in a laboratory and used to treat growth hormone deficiency.<\/jats:p>","DOI":"10.1177\/20420188241308446","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T01:21:56Z","timestamp":1739150516000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A study looking at how missed somatropin injections affect growth in children with growth hormone deficiency: a plain language summary of publication"],"prefix":"10.1177","volume":"16","author":[{"given":"Jane","family":"Loftus","sequence":"first","affiliation":[{"name":"Pfizer Limited, Tadworth, Surrey, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley S.","family":"Miller","sequence":"additional","affiliation":[{"name":"University of Minnesota Masonic Children\u2019s Hospital, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig S.","family":"Parzynski","sequence":"additional","affiliation":[{"name":"Genesis Research, Hoboken, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Alvir","sequence":"additional","affiliation":[{"name":"Pfizer Inc., New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Pfizer Inc., Collegeville, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priti","family":"Jhingran","sequence":"additional","affiliation":[{"name":"Genesis Research, Hoboken, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Gupta","sequence":"additional","affiliation":[{"name":"Pfizer Inc., New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitch","family":"DeKoven","sequence":"additional","affiliation":[{"name":"IQVIA, Falls Church, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Divino","sequence":"additional","affiliation":[{"name":"IQVIA, Falls Church, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Tse","sequence":"additional","affiliation":[{"name":"IQVIA, Falls Church, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"IQVIA, Falls Church, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wajnrajch","sequence":"additional","affiliation":[{"name":"Pfizer Inc., New York, NY, USA"},{"name":"New York University Langone Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,9]]},"container-title":["Therapeutic Advances in Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20420188241308446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20420188241308446","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20420188241308446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:36:44Z","timestamp":1777592204000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20420188241308446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":0,"alternative-id":["10.1177\/20420188241308446"],"URL":"https:\/\/doi.org\/10.1177\/20420188241308446","relation":{},"ISSN":["2042-0188","2042-0196"],"issn-type":[{"value":"2042-0188","type":"print"},{"value":"2042-0196","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"article-number":"20420188241308446"}}