{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:44:25Z","timestamp":1784126665452,"version":"3.55.0"},"reference-count":70,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The effectiveness of vitamin D supplementation in the progression of diabetic kidney disease (DKD) remains controversial. Our review tries to provide a comprehensive summary of all the relevant articles in the area to assess the association of vitamin D deficiency with the development of DKD and the effect of vitamin D supplementation on the progression of DKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PubMed, Embase, Scopus, Cochrane Library and Web of Science were accessed from inception till June 2024 to obtain all the relevant meta-analyses assessing the function of vitamin D in the onset and prognosis of DKD. The summary data were extracted by two independent reviewers. A Measurement Tool to Assess Systematic Reviews (AMSTAR) 2 tool was used for the assessment of the methodological quality of the included meta-analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 4579 articles were obtained from 5 databases in the initial search, of which 8 meta-analyses were included for the evidence synthesis. The methodological quality of the retrieved articles ranged from critically low to high. Serum vitamin D levels were significantly correlated with the prevalence of DKD. The review suggested that vitamin D supplementation could help in reducing proteinuria. However, no such changes were observed in other renal function parameters of DKD patients following vitamin D supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The current evidence indicates that vitamin D supplementation could be beneficial in reducing proteinuria among DKD patients.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>PROSPERO registration number:<\/jats:bold>\n                      CRD42022375194.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420188251319476","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T06:30:31Z","timestamp":1745649031000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of vitamin D in the development and progression of diabetic kidney disease: an overview of meta-analyses"],"prefix":"10.1177","volume":"16","author":[{"given":"Ashna","family":"Chackochan","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha R.","family":"Reghunath","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja Gopal","family":"Poojari","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Thunga","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivashankara Kaniyoor","family":"Nagri","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasudeva","family":"Guddattu","sequence":"additional","affiliation":[{"name":"Department of Data Science, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revathi P.","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Prasad Shenoy","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-1573","authenticated-orcid":false,"given":"Leelavathi D.","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Udupi District, Manipal, Karnataka - 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71908-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4711-2"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012070718"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-021-02373-3"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2023.05.006"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00022729"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2704"},{"key":"e_1_3_4_9_2","first-page":"1517","article-title":"Vitamin D insufficiency in a population of healthy western Canadians","volume":"166","author":"Rucker D","year":"2002","unstructured":"Rucker D, Allan JA, Fick GH, et al. 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