{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:19:28Z","timestamp":1777879168897,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Exercise has been suggested to effectively improve cardiac performance in children with type 1 diabetes (T1D) by enhancing the glycemic control. The purpose of this study was to investigate (1) effects of a 12-week combined interval running and resistance training (CIRRT) and (2) 1 month of detraining on cardiac structure and myocardial performance in adolescent males with T1D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 72 participants, including 48 adolescent males with T1D (fasting blood glucose (FBG): 274.67\u2009\u00b1\u200952.99\u2009mg\/dL, age: 15.20\u2009\u00b1\u20091.78\u2009years) and 24 healthy adolescents (FBG: 90.75\u2009\u00b1\u20095.47\u2009mg\/dL, age: 15.08\u2009\u00b1\u20091.67\u2009years), were recruited to the study. Participants were allocated into diabetes exercise (DE), diabetes control (DC), and healthy controls (HC) groups. The DE group performed 12\u2009weeks of a CIRRT program three times per week. Blood glucose profile, echocardiography (ECHO) indices, and peak oxygen consumption (VO\n                      <jats:sub>2peak<\/jats:sub>\n                      ) were measured pre- and post-intervention and following 1-month detraining period. Repeated measures ANOVA was used for pre- and post-intervention comparisons within the DE group and across the three study groups. Significance level was set at\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Exercise intervention resulted in decreased hemoglobin A1c (HbA1c%\u2009=\u2009Pre: 10.44\u2009\u00b1\u20092.03, Post: 9.38\u2009\u00b1\u20091.66,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05), FBG, left ventricular (LV) internal diameter, and both tricuspid and mitral deceleration time (DT) in the DE group. VO\n                      <jats:sub>2peak<\/jats:sub>\n                      , ejection fraction (EF%\u2009=\u2009Pre: 62.38\u2009\u00b1\u20091.6, Post: 64.08\u2009\u00b1\u20091.18,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05), fractional shortening, early tricuspid diastolic inflow E velocity, and tricuspid velocity during atrial contraction were also increased following the exercise training. HbA1c (Pre vs Follow-up: 9.83\u2009\u00b1\u20091.73,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05), EF (Pre vs Follow-up: 62.97\u2009\u00b1\u20091.56,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05), LV, and DT tricuspid remained significantly improved after detraining period compared to the baseline. In the baseline, the glycemic index and ECHO variable significantly differed in the DE and DC groups with the HC group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). However, after the intervention, the DC and HC groups did not change significantly (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The CIRRT intervention was associated with improved cardiac structure and performance in male adolescents with T1D potentially due to exercise-induced adaptations. Meanwhile, the results indicate that most cardiac morphological and functional changes are reversible following periods of inactivity in patients with T1D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420188251325148","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T09:45:09Z","timestamp":1743241509000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of 12-week combined interval running and resistance training on cardiac structure and performance in patients with type 1 diabetes"],"prefix":"10.1177","volume":"16","author":[{"given":"Hossein","family":"Saki","sequence":"first","affiliation":[{"name":"Department of Exercise Physiology, Sports Science Faculty, Bu-Ali Sina University, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4040-0837","authenticated-orcid":false,"given":"Farzad","family":"Nazem","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Sports Science Faculty, Bu-Ali Sina University, Hamadan 65174, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0509-9172","authenticated-orcid":false,"given":"Omid","family":"Khaiyat","sequence":"additional","affiliation":[{"name":"School of Health and Sport Sciences, Liverpool Hope University, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farnaz","family":"Fariba","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"issue":"1","key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13098-023-01014-z","article-title":"Residual \u03b2-cell function in Brazilian type 1 diabetes after 3 years of diagnosis: prevalence and association with low presence of nephropathy","volume":"15","author":"Gabbay MA","year":"2023","unstructured":"Gabbay MA, Crispim F, Dib SA. 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