{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:19:39Z","timestamp":1777879179010,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Body mass index (BMI) and sarcopenia are linked to osteoporosis, but the extent to which BMI influences osteoporosis through sarcopenia remains unclear. This study aims to assess the associations between BMI, sarcopenia, and osteoporosis, and to explore the predictive value of their combined biochemical markers for osteoporosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We retrospectively collected clinical data from 813 inpatients in the endocrinology department to explore the relationships between serum markers and skeletal muscle mass or BMI, and to evaluate the predictive value of BMI and sarcopenia for osteoporosis. Mediation analysis was employed to examine the associations among BMI, sarcopenia, and osteoporosis. Participants were randomly divided into training (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009407) and testing (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009406) sets (5:5). Independent risk factors were identified using least absolute shrinkage and selection operator and logistic regression, leading to the development of a nomogram model. Model evaluation was conducted through receiver operating characteristic curves, confusion matrices, calibration curves, decision curve analysis (DCA), and clinical impact curves (CIC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>BMI and skeletal muscle mass were negatively correlated with serum 25-hydroxyvitamin D and calcium levels. The \u201cBMI\u2009&lt;\u200928 and Non-Sarcopenia\u201d emerged as a protective factor against osteoporosis. Sarcopenia significantly mediated the association between BMI and osteoporosis (46.88%). Gender, age, high-density lipoprotein, alkaline phosphatase, BMI, and sarcopenia emerged as independent predictors of osteoporosis. The area under the curve (AUC) for the training and testing sets was 0.859 and 0.866, respectively, with calibration curves indicating good consistency. DCA and CIC demonstrated clinical net benefits at risk thresholds of 0.02\u20130.82 and 0.02\u20130.67. Sankey diagrams and partial AUCs (1.00\u20130.75 sensitivity and specificity) illustrate the significant negative predictive value of BMI and sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Lower BMI and non-sarcopenia are negatively associated with the risk of osteoporosis. In addition, the nomogram demonstrates good predictive value, with a greater negative predictive value of the BMI and sarcopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420188251332055","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T01:00:44Z","timestamp":1745888444000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of body mass index and sarcopenia with osteoporosis: a predictive nomogram model for risk assessment"],"prefix":"10.1177","volume":"16","author":[{"given":"Qingling","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Endocrinology, Huining County People\u2019s Hospital, Huining County, Gansu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengquan","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Interventional Vascular Medicine, Hefei Hospital Affiliated to Anhui Medical University, The Second People\u2019s Hospital of Hefei, Hefei City, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Interventional Vascular Medicine, Hefei Hospital Affiliated to Anhui Medical University, The Second People\u2019s Hospital of Hefei, 574 Changjiang East Road, Yaohai District, Hefei City, Anhui Province 230011, China"},{"name":"The Fifth Clinical College of Medicine, Anhui Medical University, Hefei City, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2595-2373","authenticated-orcid":false,"given":"Shiwu","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Interventional Vascular Medicine, Hefei Hospital Affiliated to Anhui Medical University, The Second People\u2019s Hospital of Hefei, 574 Changjiang East Road, Yaohai District, Hefei City, Anhui Province 230011, China"},{"name":"The Fifth Clinical College of Medicine, Anhui Medical University, Hefei City, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-022-01061-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2225-1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-021-01213-6"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00391-019-01553-z"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.03.002"},{"issue":"11","key":"e_1_3_4_7_2","first-page":"849","article-title":"Osteosarcopenia: a new geriatric syndrome","volume":"46","author":"Hassan EB","year":"2017","unstructured":"Hassan EB, Duque G. 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