{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:19:32Z","timestamp":1777879172668,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"Summary<\/jats:title>\n \n Researchers looked at data from the largest and longest-running database of children with growth disorders who were treated with daily injections of a brand of growth\n hormone<\/jats:bold>\n called\n Genotropin<\/jats:bold>\n . The researchers used these data to better understand the safety and effectiveness of daily growth\n hormone<\/jats:bold>\n treatment.\n <\/jats:p>\n \n Researchers showed that daily growth\n hormone<\/jats:bold>\n treatment:\n <\/jats:p>\n \u25cb\u2003Increased the children\u2019s heights, measured after 1\u2009year of treatment. This was seen for all of the growth disorders studied.<\/jats:p>\n \u25cb\u2003Increased growth in children of different ages, with higher growth seen in children who had begun treatment before they started puberty.<\/jats:p>\n \u25cb\u2003Allowed short children to reach an adult height within the normal range. This was true even for children who did not begin treatment until early adolescence.<\/jats:p>\n \n \u25cb\u2003Was safe. Only a very small percentage (3%) of children had any side effects related to growth\n hormone<\/jats:bold>\n treatment, the most common of which was headaches.\n <\/jats:p>\n \n When children reach the end of puberty, their growth plates close and they are unable to grow any taller. Once this happens, growth\n hormone<\/jats:bold>\n treatment cannot increase their growth further and treatment should be stopped.\n <\/jats:p>\n \n The purpose of this plain language summary is to help you to understand the findings from recent research.<\/jats:bold>\n <\/jats:p>\n \n \n \n \n Somatropin<\/jats:bold>\n is used to treat the conditions under study that are discussed in this summary. Approval varies by country; please check with your local healthcare provider for more details.\n <\/jats:p>\n <\/jats:list-item>\n \n The results of this study may differ from those of other studies. Health professionals should make treatment decisions based on all available evidence and not on the results of a single study.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>","DOI":"10.1177\/20420188251345556","type":"journal-article","created":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T07:53:22Z","timestamp":1755417202000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A database study of the safety and effectiveness of daily growth hormone in treating more than 80,000 children with growth disorders worldwide: a plain language summary of publication"],"prefix":"10.1177","volume":"16","author":[{"given":"Mohamad","family":"Maghnie","sequence":"first","affiliation":[{"name":"Department of Pediatrics, IRCCS Giannina Gaslini, Genova, Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Ranke","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, University Children\u2019s Hospital, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell E.","family":"Geffner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Saban Research Institute, Children\u2019s Hospital Los Angeles, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elpis","family":"Vlachopapadopoulou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Growth and Development, Children\u2019s Hospital P. & A. Kyriakou, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Endocrinologia Metab\u00f2lica, Institut de Recerca Sant Joan de D\u00e9u (Department of Endocrinology and Metabolic Endocrinology, Institut de Recerca Sant Joan de D\u00e9u), University of Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas, Instituto de Salud Carlos III (Biomedical Research Center for Diabetes and Associated Metabolic Diseases, Carlos III Health Institute), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology, Pfizer Inc., New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Cutfield","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology, Liggins Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul","family":"Rooman","sequence":"additional","affiliation":[{"name":"PendoCon, Putte, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Gomez","sequence":"additional","affiliation":[{"name":"Pfizer Biopharmaceuticals Group, Pfizer Pte Ltd, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Wajnrajch","sequence":"additional","affiliation":[{"name":"Rare Disease, Biopharmaceuticals, Pfizer, New York, NY, USA"},{"name":"Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Linglart","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetology for Children, AP-HP, Bic\u00eatre Paris Saclay, Le Kremlin Bic\u00eatre (Bic\u00eatre Paris Saclay, The Kremlin Bic\u00eatre), France"},{"name":"APHP, Reference Center for Rare Diseases of Calcium and Phosphate Metabolism, and Fili\u00e8re OSCAR, endo ERN and ERN BOND, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Stawerska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Polish Mother\u2019s Memorial Hospital\u2014Research Institute, Lodz, Poland"},{"name":"Department of Paediatric Endocrinology, Medical University of Lodz, Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter E.","family":"Clayton","sequence":"additional","affiliation":[{"name":"Developmental Biology and Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feyza","family":"Darendeliler","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit, \u0130stanbul Faculty of Medicine, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita C. S.","family":"Hokken-Koelega","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Horikawa","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Tanaka Growth Clinic, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmuth-G\u00fcnther","family":"D\u00f6rr","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University of Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Polak","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology, Gynaecology and Diabetology Department, H\u00f4pital Universitaire Necker Enfants Malades, Universit\u00e9 de Paris Cit\u00e9 (Necker Children\u2019s University Hospital, University of Paris City), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adda","family":"Grimberg","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,17]]},"container-title":["Therapeutic Advances in Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20420188251345556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20420188251345556","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20420188251345556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:36:53Z","timestamp":1777592213000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20420188251345556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":0,"alternative-id":["10.1177\/20420188251345556"],"URL":"https:\/\/doi.org\/10.1177\/20420188251345556","relation":{},"ISSN":["2042-0188","2042-0196"],"issn-type":[{"value":"2042-0188","type":"print"},{"value":"2042-0196","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"20420188251345556"}}