{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:19:38Z","timestamp":1777879178039,"version":"3.51.4"},"reference-count":98,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is a chronic, heterogeneous and prevalent endocrine-metabolic condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aims to synthesize the available evidence on the comparison of lipid accumulation product (LAP) and visceral adiposity index (VAI) in women with and without PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources and methods:<\/jats:title>\n                    <jats:p>A systematic search was executed across five electronic databases. Continuous variables were assessed using the standardized mean difference (SMD) and its 95% confidence interval (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 46 studies were included (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912,442). PCOS patients have higher values of LAP (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200910,658; SMD: 0.65; 95% CI: 0.47\u20130.83,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200993.65%) and VAI (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20097930; SMD: 0.53; 95% CI: 0.21\u20130.85;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200997.24%) compared to those without the syndrome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Women with PCOS show significantly higher VAI and LAP values than those without this syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420188251397203","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T10:56:43Z","timestamp":1763981803000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipid accumulation product and visceral adiposity index in women with and without polycystic ovary syndrome: a systematic review and meta-analysis"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1093-4937","authenticated-orcid":false,"given":"Juan R.","family":"Ulloque-Badaracco","sequence":"first","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, 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