{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:03:22Z","timestamp":1784365402734,"version":"3.55.0"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004850","name":"Gaziosmanpasa \u00dcniversitesi","doi-asserted-by":"publisher","award":["2023\/78"],"award-info":[{"award-number":["2023\/78"]}],"id":[{"id":"10.13039\/501100004850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004850","name":"Gaziosmanpasa \u00dcniversitesi","doi-asserted-by":"publisher","award":["2026\/102"],"award-info":[{"award-number":["2026\/102"]}],"id":[{"id":"10.13039\/501100004850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Endocrinology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The pathogenesis of diabetes is affected by a complex interplay between numerous environmental and genetic factors. While single-nucleotide polymorphisms (SNPs) are not directly used as biomarkers of the disease, they can be considered an important guide for determining predisposition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the roles of raftlin, malondialdehyde (MDA), superoxide dismutase (SOD), and the vitamin D receptor (VDR) BsmI (rs1544410 A&gt;G) polymorphism, in the clinical progression of type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A retrospective observational case\u2013control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 300 subjects were included in the study: 104 with T2DM, 85 with prediabetes, and 111 healthy controls. The VDR BsmI polymorphism was genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, while serum MDA, SOD, and raftlin were analyzed via the enzyme-linked immunosorbent assay (ELISA) method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      No statistically significant differences were observed in the allelic and genotype frequencies of the VDR gene BsmI polymorphism between T2DM prediabetes patients and controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.97,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.58, respectively). MDA levels were higher, while raftlin levels were lower in patients with T2DM and prediabetes compared to controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Within the T2DM cohort, HbA1c (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.014), MDA (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001), and raftlin (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) differed significantly between the BB and bb genotypes, with a positive correlation between the bb genotype and HbA1c (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.287). Receiver operating characteristic (ROC) analysis revealed raftlin\u2019s diagnostic potential among T2DM patients with the BB and bb genotypes, with an area under the curve (AUC) of 0.839, a specificity of 69.2%, and a sensitivity of 81.5%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>To the best of our knowledge, this is the first study to demonstrate that raftlin exhibits significant diagnostic efficacy in individuals with the bb genotype within a clinical T2DM cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420188261460573","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:11:26Z","timestamp":1784178686000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Determination of the relationship between raftlin, oxidative stress levels, and vitamin D receptor gene polymorphism in diabetic patients"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2796-9511","authenticated-orcid":false,"given":"Figen","family":"Guzelgul","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Tokat Gaziosmanpa\u015fa University, Tokat, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihan","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Tokat Gaziosmanpa\u015fa University, Tokat, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2654-3911","authenticated-orcid":false,"given":"Merve","family":"Catak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Tokat Gaziosmanpa\u015fa University, Tokat, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kubra","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Tokat Gaziosmanpa\u015fa University, Tokat, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0695-326X","authenticated-orcid":false,"given":"Marwa","family":"Abdelmageed","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Tokat Gaziosmanpa\u015fa University, Tokat 60030, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-3988","authenticated-orcid":false,"given":"Shahab Ahmed Salih","family":"Gezh","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, Kalar Technical Institute, Garmian Polytechnic University, Kalar, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-9102","authenticated-orcid":false,"given":"Sadegul","family":"Savkin","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Tokat Gaziosmanpa\u015fa University, Tokat, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad284"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i6.850"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0806"},{"key":"e_1_3_4_6_2","article-title":"Burden of illness in type 2 diabetes mellitus","volume":"24","author":"Cannon A","year":"2018","unstructured":"Cannon A, Handelsman Y, Heile M, et al. 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