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Recently, some studies have demonstrated the efficacy of this new method in reducing congenital abnormalities with specific origin; for example, in the offspring of diabetic and epileptic mothers, and in pregnancy with high fever. The benefits and drawbacks of four possible uses of periconception folate\/folic acid and multivitamin supplementation are discussed: we believe there has been a missed opportunity to implement this preventive approach in medical practice. The four methods are as follows: (i) dietary intake of folate and other vitamins, (ii) periconception folic acid\/multivitamin supplementation, (iii) food fortification with folic acid, and (iv) the combination of oral contraceptives with 6S-5-methytetrahydrofolate (\u2018folate\u2019).<\/jats:p>","DOI":"10.1177\/2042098611411358","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T08:03:45Z","timestamp":1311840225000},"page":"173-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Primary prevention of neural-tube defects and some other congenital abnormalities by folic acid and multivitamins: history, missed opportunity and tasks"],"prefix":"10.1177","volume":"2","author":[{"given":"Andrew E.","family":"Czeizel","sequence":"first","affiliation":[{"name":"T\u00f6r\u00f6kv\u00e9sz lejt\u00f5 32, 1026 Budapest, 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