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ADR risk increases with age-related changes in pharmacokinetics and pharmacodynamics, increasing burden of comorbidity, polypharmacy, inappropriate prescribing and suboptimal monitoring of drugs. ADRs are a preventable cause of harm to patients and an unnecessary waste of healthcare resources. Several ADR risk tools exist but none has sufficient predictive value for clinical practice. Good clinical practice for detecting and predicting ADRs in vulnerable patients includes detailed documentation and regular review of prescribed and over-the-counter medications through standardized medication reconciliation. New medications should be prescribed cautiously with clear therapeutic goals and recognition of the impact a drug can have on multiple organ systems. Prescribers should regularly review medication efficacy and be vigilant for ADRs and their contributory risk factors. Deprescribing should occur at an individual level when drugs are no longer efficacious or beneficial or when safer alternatives exist. Inappropriate prescribing and unnecessary polypharmacy should be minimized. Comprehensive geriatric assessment and the use of explicit prescribing criteria can be useful in this regard.<\/jats:p>","DOI":"10.1177\/2042098615615472","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T21:13:16Z","timestamp":1447708396000},"page":"11-22","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":385,"title":["Predicting risk of adverse drug reactions in older adults"],"prefix":"10.1177","volume":"7","author":[{"given":"Amanda Hanora","family":"Lavan","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, Cork University Hospital, Wilton, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Cork University Hospital, Wilton, Cork, 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