{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:27:15Z","timestamp":1793060835455,"version":"4.5.0"},"reference-count":117,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Drug Safety"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Medication harm can lead to hospital admission, prolonged hospital stay and poor patient outcomes. Reducing medication harm is a priority for healthcare organisations worldwide. Recent Australian studies demonstrate cardiovascular (CV) medications are a leading cause of harm. However, they appear to receive less recognition as \u2018high risk\u2019 medications compared with those classified by the medication safety acronym, \u2018APINCH\u2019 (antimicrobials, potassium, insulin, narcotics, chemotherapeutics, heparin). Our aim was to determine the scale and type of medication harm caused by CV medications in healthcare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A narrative review of adult (&gt;16\u2009years) medication harm literature identified from PubMed and CINAHL databases was undertaken. Studies with the primary outcome of measuring the incidence of medication harm were included. Harm caused by CV medications was described and ranked against other medication classes at four key stages of a patient\u2019s healthcare journey. Where specified, the implicated medications and type of harm were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 75 studies were identified, including seven systematic reviews and three meta-analyses, with most focussing on harm causing hospital admission. CV medications were responsible for approximately 20% of medication harm; however, this proportion increased to 50% in older populations. CV medications were consistently ranked in the top five medication categories causing harm and were often listed as the leading cause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CV medications are a leading cause of medication harm, particularly in older adults, and should be the focus of harm mitigation strategies. A practical approach to generate awareness among health professionals is to incorporate \u2018C\u2019 (for CV medications) into the \u2018APINCH\u2019 acronym.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language summary<\/jats:title>\n                    <jats:p>Patient harm from cardiovascular medications Background \u2022\u2003Harm from medications can cause poor patient outcomes. \u2022\u2003Certain medications have been identified as \u2018high risk\u2019 and are known to cause high rates of harm. \u2022\u2003\u2018High risk\u2019 medications are included in medication guidelines used by health professionals. \u2022\u2003Cardiovascular medications (e.g. blood pressure and cholesterol medications) are important and have many benefits. \u2022\u2003Recent studies have found cardiovascular medications to cause high rates of harm. \u2022\u2003Cardiovascular medication harm is often under-recognised in clinical practice. \u2022\u2003Some guidelines do not consider cardiovascular medications to be \u2018high risk\u2019. Method \u2022\u2003This review investigated the extent of harm caused by cardiovascular medications in adults across four healthcare settings: (1) at the time of hospital admission; (2) during hospital admission; (3) after hospital; and (4) readmission to hospital. \u2022\u2003Harm caused by cardiovascular medications was ranked against other medication classes. \u2022\u2003We investigated the type of cardiovascular medications to cause harm and the type of harm caused. Results \u2022\u2003Seventy-five studies were reviewed across 41 countries. \u2022\u2003Cardiovascular medications were ranked within the top five medications to cause harm. \u2022\u2003Cardiovascular medications were a leading cause of harm in each healthcare setting investigated. \u2022\u2003Harm caused by cardiovascular medications was common in older adults (&gt;65\u2009years). \u2022\u2003Cardiovascular medications often caused preventable harm. \u2022\u2003Medications to treat high blood pressure and abnormal heart rhythms were the most common causes of harm. \u2022\u2003We reported kidney injury, electrolyte changes and low blood pressure as common types of harm. Conclusion \u2022\u2003Increased focus on cardiovascular medications in clinical practice is needed. \u2022\u2003Health professionals need to carefully prescribe and frequently review cardiovascular medications, especially in older adults. \u2022\u2003Patient and health professional discussions should be based on both the benefits and harms of cardiovascular medications. \u2022\u2003Cardiovascular medications should be included in all \u2018high risk\u2019 medication guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420986211027451","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:34:46Z","timestamp":1627259686000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Patient harm from cardiovascular medications"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-6761","authenticated-orcid":false,"given":"Chariclia","family":"Paradissis","sequence":"first","affiliation":[{"name":"School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, 20 Cornwall Street, Woolloongabba, Brisbane, QLD 4102, Australia"},{"name":"Pharmacy Department, Royal Brisbane and Women\u2019s Hospital, Metro North Health, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Cottrell","sequence":"additional","affiliation":[{"name":"School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Coombes","sequence":"additional","affiliation":[{"name":"School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia"},{"name":"Pharmacy Department, Royal Brisbane and Women\u2019s Hospital, Metro North Health, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7596-0837","authenticated-orcid":false,"given":"Ian","family":"Scott","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia"},{"name":"Department of Internal Medicine and Clinical Epidemiology, Princess Alexandra Hospital, Metro South Health, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia"},{"name":"Department of Cardiology, Princess Alexandra Hospital, Metro South Health, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Barras","sequence":"additional","affiliation":[{"name":"School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia"},{"name":"Pharmacy Department, Princess Alexandra Hospital, Metro South Health, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,25]]},"reference":[{"key":"bibr1-20420986211027451","volume-title":"Australia","author":"Australian Institute of Health and Welfare","year":"2018"},{"key":"bibr2-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530010043033"},{"key":"bibr3-20420986211027451","first-page":"U271","volume":"115","author":"Davis P","year":"2002","journal-title":"N Z Med J"},{"key":"bibr4-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199102073240605"},{"key":"bibr5-20420986211027451","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1995.tb124691.x"},{"key":"bibr6-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1103053"},{"key":"bibr7-20420986211027451","volume-title":"Literature review: medication safety in Australia","author":"Roughead L","year":"2013"},{"key":"bibr8-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000075"},{"key":"bibr9-20420986211027451","unstructured":"World Health Organization. The third WHO global patient safety challenge: medication without harm, https:\/\/www.who.int\/patientsafety\/medication-safety\/en\/ (2019, accessed 29 August 2019)."},{"key":"bibr10-20420986211027451","unstructured":"Pharmaceutical Society of Australia. Medicine safety to be the 10th National Health Priority area, https:\/\/www.psa.org.au\/ (2019, accessed 30 July 2020)."},{"key":"bibr11-20420986211027451","unstructured":"The Hon Greg Hunt MP. Doorstop interview about the COAG health ministers meeting, https:\/\/www.health.gov.au\/ministers\/the-hon-greg-hunt-mp\/media\/doorstop-interview-about-the-coag-health-ministers-meeting (2019, accessed 30 July 2020)."},{"key":"bibr12-20420986211027451","unstructured":"Australian Commission on Safety and Quality in Health Care. APINCHS classification of high risk medicines, https:\/\/www.safetyandquality.gov.au\/our-work\/medication-safety\/high-risk-medicines\/apinchs-classification-high-risk-medicines (2019, accessed 8 November 2019)."},{"key":"bibr13-20420986211027451","unstructured":"Australian Commission on Safety and Quality in Health Care. High risk medicines, https:\/\/www.safetyandquality.gov.au\/our-work\/medication-safety\/high-risk-medicines (2019, accessed 12 December 2019)."},{"key":"bibr14-20420986211027451","unstructured":"Institute for Safe Medication Practices. High-alert medications in acute care settings, https:\/\/www.ismp.org\/recommendations\/high-alert-medications-acute-list (2018, accessed 10 September 2019)."},{"key":"bibr15-20420986211027451","unstructured":"Clinical Excellence Commission. High-risk medicines, http:\/\/www.cec.health.nsw.gov.au\/patient-safety-programs\/medication-safety\/high-risk-medicines\/A-PINCH (2019, accessed 8 November 2019)."},{"key":"bibr16-20420986211027451","unstructured":"Australian Institute of Health and Welfare. Medicines for cardiovascular disease. Cat. no. CVD 80. Canberra: AIHW, 2017."},{"key":"bibr17-20420986211027451","first-page":"728","volume":"39","author":"Holbeach E","year":"2010","journal-title":"Aust Fam Physician"},{"key":"bibr18-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2016.06.789"},{"key":"bibr19-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00193-6"},{"key":"bibr20-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0473-y"},{"key":"bibr21-20420986211027451","doi-asserted-by":"publisher","DOI":"10.18549\/PharmPract.2016.02.706"},{"key":"bibr22-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1002\/jppr.1255"},{"key":"bibr23-20420986211027451","volume-title":"Prioritising patients at high-risk of medication harm: Development and validation of risk prediction models [dissertation]","author":"Falconer N","year":"2019"},{"key":"bibr24-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-018-2567-5"},{"key":"bibr25-20420986211027451","unstructured":"Australian medicines handbook online [Internet]. Adelaide (S. Australia): Australian Medicines Handbook Pty Ltd, 2020. Cardiovascular drugs, https:\/\/amhonline.amh.net.au\/chapters\/cardiovasculardrugs?menu=banner (2020, accessed 30 July 2020)."},{"key":"bibr26-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-010-0536-7"},{"key":"bibr27-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.06.009"},{"key":"bibr28-20420986211027451","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-11-200712040-00006"},{"key":"bibr29-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2001.00044.x"},{"key":"bibr30-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1992.tb04001.x"},{"key":"bibr31-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A333"},{"key":"bibr32-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1002\/pds.667"},{"key":"bibr33-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50607.x"},{"key":"bibr34-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7456.15"},{"key":"bibr35-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2008.01.004"},{"key":"bibr36-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L037"},{"key":"bibr37-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-016-2084-3"},{"key":"bibr38-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzg085"},{"key":"bibr39-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02698.x"},{"key":"bibr40-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12293"},{"key":"bibr41-20420986211027451","first-page":"2079","volume":"9","author":"Alhawassi TM","year":"2014","journal-title":"Clin Interv Aging"},{"key":"bibr42-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2225-3"},{"key":"bibr43-20420986211027451","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb138996.x"},{"key":"bibr44-20420986211027451","first-page":"1","volume-title":"Database of Abstracts of Reviews of Effects (DARE): quality-assessed reviews","author":"Wiffen P","year":"2002"},{"key":"bibr45-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-016-0444-7"},{"key":"bibr46-20420986211027451","first-page":"90","volume":"21","author":"Larmour I","year":"1991","journal-title":"Aust J Hosp Pharm"},{"key":"bibr47-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.1994.tb00691.x"},{"key":"bibr48-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1996.tb03658.x"},{"key":"bibr49-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1002\/pds.568"},{"key":"bibr50-20420986211027451","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2005.tb06698.x"},{"key":"bibr51-20420986211027451","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522090-00005"},{"key":"bibr52-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.15.1858"},{"key":"bibr53-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.01130.x"},{"key":"bibr54-20420986211027451","first-page":"389","volume":"14","author":"Edwards DB","year":"2007","journal-title":"J Clin Outcomes Manag"},{"key":"bibr55-20420986211027451","doi-asserted-by":"crossref","first-page":"135","DOI":"10.25100\/cm.v39i2.569","volume":"39","author":"Ocampo JM","year":"2008","journal-title":"Colomb Med"},{"key":"bibr56-20420986211027451","doi-asserted-by":"publisher","DOI":"10.3109\/08923970903468847"},{"key":"bibr57-20420986211027451","doi-asserted-by":"publisher","DOI":"10.2147\/DHPS.S29287"},{"key":"bibr58-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03772.x"},{"key":"bibr59-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12455"},{"key":"bibr60-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1071\/AH12027"},{"key":"bibr61-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-017-0177-y"},{"key":"bibr62-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-017-0528-z"},{"key":"bibr63-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4184"},{"key":"bibr64-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13961"},{"key":"bibr65-20420986211027451","first-page":"251","volume":"115","author":"Schurig AM","year":"2018","journal-title":"Dtsch Arztebl Int"},{"key":"bibr66-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/ajag.12712"},{"key":"bibr67-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14134"},{"key":"bibr68-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s40267-019-00700-1"},{"key":"bibr69-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004439"},{"key":"bibr70-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/60.17.1750"},{"key":"bibr71-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs046"},{"key":"bibr72-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2009.01.010"},{"key":"bibr73-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015570104121"},{"key":"bibr74-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2330-3"},{"key":"bibr75-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2018.05.006"},{"key":"bibr76-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540280039031"},{"key":"bibr77-20420986211027451","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200222060-00006"},{"key":"bibr78-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E559"},{"key":"bibr79-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-010-0010-4"},{"key":"bibr80-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-010-1518-3"},{"key":"bibr81-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1071\/AH13166"},{"key":"bibr82-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13199"},{"key":"bibr83-20420986211027451","first-page":"21","volume":"130","author":"Robb G","year":"2017","journal-title":"N Z Med J"},{"key":"bibr84-20420986211027451","doi-asserted-by":"publisher","DOI":"10.21019\/9781582120928"},{"key":"bibr85-20420986211027451","volume-title":"Guiding principles to achieve continuity in medication management","author":"Australian Pharmaceutical Advisory Council","year":"2005"},{"key":"bibr86-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15244"},{"key":"bibr87-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.5.511"},{"key":"bibr88-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12504"},{"key":"bibr89-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2005.30390.x"},{"key":"bibr90-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.9.1107"},{"key":"bibr91-20420986211027451","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-3-200302040-00007"},{"key":"bibr92-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15419"},{"key":"bibr93-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa020703"},{"key":"bibr94-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2016.1131816"},{"key":"bibr95-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1080\/01621424.2018.1454372"},{"key":"bibr96-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13613"},{"key":"bibr97-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19036"},{"key":"bibr98-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03751.x"},{"key":"bibr99-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02839.x"},{"key":"bibr100-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1177\/1060028018818571"},{"key":"bibr101-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000784"},{"key":"bibr102-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.02007.x"},{"key":"bibr103-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu145"},{"key":"bibr104-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13702"},{"key":"bibr105-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.0324"},{"key":"bibr106-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1223-8"},{"key":"bibr107-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-019-00683-8"},{"key":"bibr108-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16157."},{"key":"bibr109-20420986211027451","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2013.077"},{"key":"bibr110-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.467"},{"key":"bibr111-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s11673-016-9736-y"},{"key":"bibr112-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2378-0"},{"key":"bibr113-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.018"},{"key":"bibr114-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.0354"},{"key":"bibr115-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.9059"},{"key":"bibr116-20420986211027451","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1668-z"},{"key":"bibr117-20420986211027451","volume-title":"Australian hospital statistics","author":"Australian Institute of Health and Welfare","year":"2019"}],"container-title":["Therapeutic Advances in Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20420986211027451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20420986211027451","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20420986211027451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:39:47Z","timestamp":1777592387000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20420986211027451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":117,"alternative-id":["10.1177\/20420986211027451"],"URL":"https:\/\/doi.org\/10.1177\/20420986211027451","relation":{},"ISSN":["2042-0986","2042-0994"],"issn-type":[{"value":"2042-0986","type":"print"},{"value":"2042-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"20420986211027451"}}