{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:26:16Z","timestamp":1789802776650,"version":"4.0.1"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Drug Safety"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Trends in the incidence of adverse drug reaction (ADR)\u2013related hospitalizations have been studied in the general population, but not specifically in people with dementia. This study aimed to investigate trends in the incidence of ADR-related hospitalizations among people with dementia, and identify the most commonly implicated drugs and diagnoses in these admissions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study utilized the administrative data of all adults admitted to the four major public hospitals of Tasmania, Australia, with a primary or secondary diagnosis of dementia from July 2010 to December 2019. ADR-related hospitalizations were identified by using diagnosis-based and external cause codes. The Cochran\u2013Armitage test was used to examine trends in the incidence of ADR-related hospitalizations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 7552 people with dementia admitted to the hospital at least once within the study period, 1775 (23.5%) experienced at least one ADR-related hospitalization. The estimated annual incidence of ADR-related hospitalizations increased 18% (1484\u20131760 per 100,000 population with dementia, p for trend &lt;0.05) from 2010 to 2019. For those ADR-related admissions with a drug code recorded, 19.3% were due to antithrombotics and 11.5% to antihypertensives. The most frequent ADR-related admission diagnoses were renal diseases (72.9%). Length of hospital stay and in-hospital mortality were both significantly greater for ADR-related, relative to non-ADR-related, admissions (median 7 versus 5 days and 11% versus 6.7%, respectively; p\u2004&lt;\u20040.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The annual incidence of ADR-related hospitalizations in people with dementia increased between 2010 and 2019. Antithrombotics were the most commonly implicated drug class. The ADR-related hospitalizations were associated with increased length of stay and greater mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>Adverse drug reaction\u2013related hospitalizations among people with dementia<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>This study aimed to investigate trends in hospitalizations associated with medication problems among people with dementia, and identify the most commonly implicated drugs and diagnoses in these admissions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study utilized the administrative data of all adults admitted to the four major public hospitals of Tasmania, Australia, with dementia from July 2010 to December 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The annual incidence of hospitalizations associated with medication problems among people with dementia increased nearly 20% over 10 years. The length of hospital stay and in-hospital mortality were significantly greater for hospitalizations related to medication problems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The incidence of hospitalizations associated with medication problems in people with dementia increased between 2010 and 2019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420986221080796","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T07:02:44Z","timestamp":1646982164000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Ten-year trends in adverse drug reaction\u2013related hospitalizations among people with dementia"],"prefix":"10.1177","volume":"13","author":[{"given":"Anum Saqib","family":"Zaidi","sequence":"first","affiliation":[{"name":"School of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-3882","authenticated-orcid":false,"given":"Gregory M.","family":"Peterson","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, Australia Faculty of Health, University of Canberra, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke R.E.","family":"Bereznicki","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin M.","family":"Curtain","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-7465","authenticated-orcid":false,"given":"Mohammed S.","family":"Salahudeen","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart 7005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"bibr1-20420986221080796","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02799-9"},{"key":"bibr2-20420986221080796","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2225-3"},{"key":"bibr3-20420986221080796","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-016-0444-7"},{"key":"bibr4-20420986221080796","unstructured":"World Health Organization. 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Admitted patient care NMDS 2018-19, https:\/\/meteor.aihw.gov.au\/content\/index.phtml\/itemId\/676382 (2020, accessed 8 December 2020)."},{"key":"bibr11-20420986221080796","doi-asserted-by":"publisher","DOI":"10.1111\/jphs.12160"},{"key":"bibr12-20420986221080796","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13124"},{"key":"bibr13-20420986221080796","doi-asserted-by":"publisher","DOI":"10.17061\/phrp2721716"},{"key":"bibr14-20420986221080796","unstructured":"Australian Institute of Health and Welfare. Estimated number of people with dementia, by sex, and state and territory, 2011 to 2020. Australian Institute of Health and Welfare, Canberra, 2012."},{"key":"bibr15-20420986221080796","unstructured":"Access Economics. Keeping dementia front of mind: incidence and prevalence 2009-2050. 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