{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:06:56Z","timestamp":1791994016506,"version":"4.4.0"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Shandong Pharmaceutical Society","award":["SDSYXH-KY-202104"],"award-info":[{"award-number":["SDSYXH-KY-202104"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Drug Safety"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To investigate the safety of oral iron therapy in pregnant women with iron-deficiency anemia (IDA) in the real world.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on 1792 pregnant patients with IDA who received oral iron supplements from 12 hospitals in Shandong Province from 1 April to 31 June 2021; follow-up and adverse reactions were recorded. They were divided into six groups according to the treatment drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The overall adverse reaction rate was 15.4%, and the main adverse reaction site was the digestive system. The incidence of all kinds of oral iron adverse reactions from high to low in order: compound ferrous sulfate and folic acid tablets (21.88%); iron proteinsuccinylate oral solution (20.90%); ferrous succinate tablets (19.76%); ferrous succinate sustained-release tablets (18.00%); iron polysaccharide complex capsule (12.06%); and iron dextran oral solution (6.94%). It was found that there was a significant difference in the incidence of adverse reactions among the six drugs ( p\u2009&lt;\u20090.05). Pairwise comparison showed that the incidence of adverse reactions was higher in the iron proteinsuccinylate oral solution than that in the iron polysaccharide complex capsule ( p\u2009&lt;\u20090.05). There was no significant difference in the incidence of adverse reactions in different ages ( p\u2009&gt;\u20090.05), but there was a significant difference in the incidence of adverse reactions in different gestational ages ( p\u2009&lt;\u20090.05). In Adverse Drug Reaction (ADR) patients, the adverse reaction result of most patients is recovery or improvement, and there was no serious adverse reaction outcome such as sequela and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>All the adverse reactions of oral iron were mainly gastrointestinal adverse reactions, and no heavy adverse reactions were found. Iron proteinsuccinylate oral solution has a higher incidence of adverse reactions than iron polysaccharide complex capsule. The results showed that oral iron was safer for anemia patients during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420986231181335","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T16:18:48Z","timestamp":1687623528000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety monitoring of oral iron supplements in pregnant women with anemia: a multi-center observational clinical study"],"prefix":"10.1177","volume":"14","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Ocean University of China, Qingdao, Shandong, China"},{"name":"Qingdao University Affiliated Qingdao Women and Children\u2019s Hospital, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8743-7106","authenticated-orcid":false,"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ocean University of China, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiye","family":"Hui","sequence":"additional","affiliation":[{"name":"Weifang Maternal and Child Health Hospital, Weifang, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Tengzhou Maternal and Child Health Hospital, Tengzhou, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Li","sequence":"additional","affiliation":[{"name":"Jinan Maternal and Child Health Hospital, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchao","family":"Cao","sequence":"additional","affiliation":[{"name":"Linyi Maternal and Child Health Hospital, Linyi, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zicheng","family":"Xue","sequence":"additional","affiliation":[{"name":"Zaozhuang Maternal and Child Health Hospital, Zaozhuang, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Qingdao Haici Hospital, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Shandong Qianfuo Mountain Hospital, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyong","family":"Wu","sequence":"additional","affiliation":[{"name":"The Second People\u2019s Hospital of Shandong Province, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusehng","family":"Sun","sequence":"additional","affiliation":[{"name":"Qingdao Municipal Hospital Group, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixing","family":"Yan","sequence":"additional","affiliation":[{"name":"Qingdao University Affiliated Qingdao Women and Children\u2019s Hospital, No. 217, Liaoyang East Road, North District, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"key":"bibr1-20420986231181335","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1901-3"},{"key":"bibr2-20420986231181335","volume-title":"International Fund for Agricultural Development, United Nations Children\u2019s Fund, World Food Programme, World Health Organization. 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