{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:10:49Z","timestamp":1789035049414,"version":"build-2803163510"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Science and Technology Project of Taizhou","award":["23ywa47"],"award-info":[{"award-number":["23ywa47"]}]},{"name":"The Science and Technology Project of Taizhou","award":["1902KY02"],"award-info":[{"award-number":["1902KY02"]}]},{"name":"The Medicines Health Research Fund of Zhejiang","award":["2022KY435"],"award-info":[{"award-number":["2022KY435"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Drug Safety"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study was designed to investigate the prophylactic effect of oral olanzapine in postoperative nausea and vomiting after gynecologic laparoscopic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>ASA I\u2013II, aged 18\u201375\u2009years, planned to undergo gynecologic laparoscopic surgery with general anesthesia in adult female patients. Using the randomized numbers table, the patients were placed in two groups. Oral olanzapine 5\u2009mg or placebo was given 1\u2009h before anesthesia. All patients received standard antiemetic prophylaxis with dexamethasone and granisetron. The primary outcome was nausea and\/or vomiting in the 24\u2009h after the postoperative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 250 patients were randomized, and 241 were analyzed. The primary outcome occurred in 10 of 120 patients (8.3%) in the olanzapine group and 23 of 121 patients (19.2%) in the placebo group ( p\u2009=\u20090.014). According to Kaplan\u2013Meier analysis, the probabilities of nausea and\/or vomiting in the 24\u2009h after the postoperative in the olanzapine group were lower than in the placebo group (log-rank p\u2009=\u20090.014). In a multivariate Cox analysis, the variables of use of olanzapine [hazard ratio (HR): 0.35, 95% confidence interval (CI): 0.16\u20130.79; p\u2009=\u20090.012] and use of vasoactive drugs (HR: 2.48, 95% CI: 1.07\u20135.75; p\u2009=\u20090.034) were independently associated with nausea and\/or vomiting in the 24\u2009h after the postoperative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our data suggest that olanzapine relative to placebo decreased the risk of nausea and\/or vomiting in the 24\u2009h after gynecologic laparoscopic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>The trial was registered prior to patient enrollment at The Chinese Clinical Trial Registry ( https:\/\/www.chictr.org.cn\/showproj.html?proj=166900 , link to registry page, Principal investigator: Nanjin Chen, Date of registration: 25 April 2022).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420986241244593","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T08:32:52Z","timestamp":1713429172000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Olanzapine for the prevention of postoperative nausea and vomiting after gynecologic laparoscopic surgery: a randomized controlled trial"],"prefix":"10.1177","volume":"15","author":[{"given":"Nanjin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuman","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingcang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwei","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, No. 150, Ximen Street, Taizhou 317000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5681-3663","authenticated-orcid":false,"given":"Yongpo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, No. 150, Ximen Street, 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