{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:33:58Z","timestamp":1787063638969,"version":"build-2736575974"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Beijing Health Alliance Charitable Foundation","award":["KM-20230601-01"],"award-info":[{"award-number":["KM-20230601-01"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Drug Safety"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The administration of either alfentanil or sufentanil as a single injection, combined with target-controlled infusion (TCI) of propofol, represents a frequently employed anesthetic regimen for daytime hysteroscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study was designed to evaluate and compare the safety and efficacy of alfentanil and sufentanil in the context of daytime hysteroscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A total of 160 patients, scheduled for daytime hysteroscopy, were randomly allocated into two groups: Group A and Group S respectively received alfentanil 10\u2009\u03bcg\/kg or sufentanil 0.15\u2009\u03bcg\/kg as a single intravenous injection. Both groups were given propofol with TCI for sedation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Monitoring of vital signs was conducted from pre-anesthesia through to 2\u2009h postoperatively. The primary outcome measured was hypoxemia, defined as SpO\n                      <jats:sub>2<\/jats:sub>\n                      levels below 92% for a duration of 30\u2009s, which necessitated manual positive pressure ventilation. Secondary outcomes included various perioperative complications, such as postoperative nausea and vomiting (PONV) occurring 2\u2009h after surgery, as well as hemodynamic indicators, NRS scores for pain, and other anesthesia-related data. This comprehensive dataset was meticulously documented and subsequently analyzed for comparative purposes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The analyses revealed that Group A had a significantly lower incidence of hypoxemia ( p\u2009=\u20090.002) and PONV ( p\u2009=\u20090.021). Additionally, group A demonstrated overall more stable blood pressure and heart rate, as well as higher SpO\n                      <jats:sub>2<\/jats:sub>\n                      levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>For daytime hysteroscopy, alfentanil at a dose of 10\u2009\u03bcg\/kg is safer than sufentanil at a dose of 0.15\u2009\u03bcg\/kg when combined with propofol TCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>This study was registered with the Chinese Clinical Trial Registry (The URL of registration is https:\/\/www.chictr.org.cn\/showproj.html?proj=177784 ; registration number: ChiCTR2200063939). The date of first registration was September 21, 2022.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420986241292231","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T09:50:50Z","timestamp":1730368250000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of a single intravenous infusion of alfentanil or sufentanil combined with target-controlled infusion of propofol for daytime hysteroscopy: a randomized clinical trial"],"prefix":"10.1177","volume":"15","author":[{"given":"Xiaofeng","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Women and Children\u2019s Hospital of Chongqing Medical University (Chongqing Health Center for Women and Children), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinghuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chongqing Rongchang Health Center for Women and Children, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8019-9747","authenticated-orcid":false,"given":"Xuezhu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Women and Children\u2019s Hospital of Chongqing Medical University (Chongqing Health Center for Women and Children), 120 Longshan Road, Yubei District, Chongqing 401147, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"bibr1-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00967.x"},{"key":"bibr2-20420986241292231","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1014486"},{"key":"bibr3-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1007\/s00482-019-0386-y"},{"key":"bibr4-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-052142"},{"key":"bibr5-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aef202"},{"key":"bibr6-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199401000-00004"},{"key":"bibr7-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1994.tb03376.x"},{"key":"bibr8-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4020-5947-6"},{"key":"bibr9-20420986241292231","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-11-201006010-00232"},{"key":"bibr10-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005101"},{"key":"bibr11-20420986241292231","first-page":"106","volume":"42","author":"Yuan Y","year":"2019","journal-title":"Zhonghua Jie He He Hu XI Za Zhi"},{"key":"bibr12-20420986241292231","volume":"63","author":"Hawker GA","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"bibr13-20420986241292231","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12134232"},{"key":"bibr14-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.08.015"},{"key":"bibr15-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.06.033"},{"key":"bibr16-20420986241292231","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58081132"},{"key":"bibr17-20420986241292231","volume":"63","author":"Loser S","year":"2014","journal-title":"Anaesthesist"},{"key":"bibr18-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8537(02)00081-0"},{"key":"bibr19-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0403200103"},{"key":"bibr20-20420986241292231","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2013.11.003"},{"key":"bibr21-20420986241292231","unstructured":"Brunton LL, Chabner B, Goodman LS, et al. 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