{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:50:10Z","timestamp":1790607010377,"version":"4.1.0"},"reference-count":61,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Drug Safety"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The majority of patients with alcohol use disorder (AUD) regularly take medication. Alcohol interacts negatively with many commonly prescribed drugs. However, little is known about the characteristics and frequency of potential alcohol\u2013medication and drug\u2013drug interactions in patients with AUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to determine the prevalence and characteristics of drug interactions in patients with AUD during withdrawal therapy on an addiction-specific ward.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Medication charts were analyzed and screened for potential alcohol\u2013medication and drug\u2013drug interactions. For the screening of potential alcohol\u2013medication interactions, the drugs.com classification was utilized and potential drug\u2013drug interactions were identified using the mediQ electronic interaction program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In our study, almost two-thirds (66.3%; 1089\/1643) of all patient cases were prescribed at least one drug that could potentially interact with alcohol. Four percent of all alcohol\u2013medication interactions were classified as severe, 91.8% as moderate, and 4.3% as mild. Drug classes commonly involved in serious interactions with alcohol were analgesics and drugs used in diabetes. A total of 811 potential drug\u2013drug interactions were identified, of which 3.3% were classified as severe and 96.5% as moderate. Psychoanaleptics (ATC N06) and psycholeptics (ATC N05) were most frequently associated with moderate to severe interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Potential alcohol\u2013medication and drug\u2013drug interactions are common in hospitalized patients with AUD. Improvements in the quality of prescribing should focus on the use of psychotropic drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420986241311214","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T07:58:17Z","timestamp":1737187097000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Drug interactions in patients with alcohol use disorder: results from a real-world study on an addiction-specific ward"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0905-274X","authenticated-orcid":false,"given":"Sebastian","family":"Schr\u00f6der","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Massarou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabea","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bleich","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phileas Johannes","family":"Proskynitopoulos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Heck","sequence":"additional","affiliation":[{"name":"Institute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schulze Westhoff","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Glahn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"bibr1-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30752-2"},{"key":"bibr2-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12330"},{"key":"bibr3-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2011.03605.x"},{"key":"bibr4-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1111\/add.14703"},{"key":"bibr5-20420986241311214","volume":"40","author":"McHugh RK","year":"2019","journal-title":"Alcohol Res"},{"key":"bibr6-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2011.00140.x"},{"key":"bibr7-20420986241311214","volume":"1","author":"Ipser JC","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr8-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-017-0621-2"},{"key":"bibr9-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75888-8"},{"key":"bibr10-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1177\/2042098620933741"},{"key":"bibr11-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1016\/j.japh.2017.06.002"},{"key":"bibr12-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-008-9191-x"},{"key":"bibr13-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.02.007"},{"key":"bibr14-20420986241311214","first-page":"40","volume":"23","author":"Weathermon R","year":"1999","journal-title":"Alcohol Res Health"},{"key":"bibr15-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-62619-6.00031-8"},{"key":"bibr16-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.11.019"},{"key":"bibr17-20420986241311214","doi-asserted-by":"publisher","DOI":"10.3109\/10826089509071060"},{"key":"bibr18-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-008-0639-4"},{"key":"bibr19-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13167"},{"key":"bibr20-20420986241311214","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12633"},{"key":"bibr21-20420986241311214","unstructured":"drugs.com. 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