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The overlap of these conditions can lead to atypical clinical manifestations, thus complicating the early diagnosis and the implementation of early treatment. This report describes the case of a patient who developed the DRESS\/SJS overlap 35\u2009days after starting antituberculosis treatment. The patient experienced severe skin and systemic involvement, a situation that required her admission and monitoring in the intensive care unit. From our experience with this case, we conclude the importance of an accurate and timely diagnosis using validated scoring systems such as RegiSCAR to confirm the clinical diagnosis of DRESS\/SJS and ALDEN to assess the likelihood of drug causality. Timely intervention with corticosteroids plays a key role in moderating the exaggerated immune response, helping to alleviate dermatological symptoms and prevent long-term organ damage. In addition, the availability of safe therapeutic alternatives for tuberculosis treatment allows for more effective and safer management in these patients.<\/jats:p>","DOI":"10.1177\/20420986241312484","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T06:41:57Z","timestamp":1737700917000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1353-0540","authenticated-orcid":false,"given":"Cristian","family":"Mor\u00e1n-Mari\u00f1os","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Bibliometr\u00eda, Vicerrectorado de investigaci\u00f3n, Unidad San Ignacio de Loyola, Av. 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