{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:02:57Z","timestamp":1793084577280,"version":"4.5.0"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100019890","name":"University of Miyazaki Hospital","doi-asserted-by":"publisher","award":["Clinical Research Support Grant"],"award-info":[{"award-number":["Clinical Research Support Grant"]}],"id":[{"id":"10.13039\/100019890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Drug Safety"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Task shifting and sharing have been proposed as strategies to address healthcare staffing shortages and improve patient outcomes. In emergency and intensive care medicine, pharmacist interventions have shown potential to reduce medication errors and improve care quality. However, the precise benefits of pharmacist support in therapeutic drug monitoring (TDM) for emergency center inpatients require further verification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To determine the contribution of pharmacist support in entering blood drug concentration test orders to patient safety during anti-methicillin-resistant\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      (MRSA) drug administration in the emergency and critical care center, and investigate the association between this support and the frequency of vancomycin-induced kidney injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Single-center retrospective cohort study comparing outcomes 2\u2009years before and 2\u2009years after implementing pharmacist support for blood concentration test order entry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients receiving intravenous vancomycin with blood concentrations measured at the emergency center were included. Propensity score matching was used to minimize confounding. The primary outcome was the change in frequency of vancomycin-induced kidney injury before and after pharmacist support implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Pharmacist support significantly reduced the frequency of vancomycin-induced kidney injury (from 6.5% to 0.0%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.043) and shortened time to first TDM implementation (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.019) in the overall cohort. Similar significant reductions were observed in the propensity score matched cohort (from 11.9% to 0.0%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Pharmacist support in entering blood drug concentration test orders significantly reduced vancomycin-induced kidney injury frequency and shortened time to first TDM, enhancing patient safety during anti-MRSA medication administration in the emergency and critical care center. This task-shifting approach demonstrates clear benefits for patient care and physician workload.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420986251339580","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:31:18Z","timestamp":1748133078000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacist support in the entry of blood drug concentration test order avoids vancomycin-induced kidney injury"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4928-0395","authenticated-orcid":false,"given":"Naoki","family":"Yoshikawa","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Miyazaki Hospital, 5200 Kihara, Kiyotake-Cho, Miyazaki 889-1692, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Miyazaki Hospital, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiko","family":"Koreeda","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Miyazaki Hospital, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Miyazaki Hospital, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Matsusaki","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Miyazaki Hospital, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusei","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Miyazaki Hospital, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenobu","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Miyazaki Hospital, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"e_1_3_4_2_2","author":"WHO","year":"2008","unstructured":"WHO. Task Shifting: rational redistribution of tasks among health workforce teams: global recommendations and guidelines. 2008.","journal-title":"Task Shifting: rational redistribution of tasks among health workforce teams: global recommendations and guidelines"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/13814788.2021.1954616"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30449-6"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2015-204726"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/08971900211000704"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2022.01.054"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.12.015"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2023.11.012"},{"key":"e_1_3_4_10_2","first-page":"23","article-title":"Establishment of a system to support entry of blood drug concentration test orders by full-time pharmacists at the emergency center","volume":"60","author":"Naoki Y","year":"2024","unstructured":"Naoki Y, Hidehiko K, Yuki M, et al. Establishment of a system to support entry of blood drug concentration test orders by full-time pharmacists at the emergency center. J Jpn Soc Hosp Pharm 2024; 60: 23\u201329.","journal-title":"J Jpn Soc Hosp Pharm"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2012.7"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05920616"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077169"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15301"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2021.07.018"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P634"}],"container-title":["Therapeutic Advances in Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20420986251339580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20420986251339580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20420986251339580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:40:55Z","timestamp":1777592455000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20420986251339580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,24]]},"references-count":16,"alternative-id":["10.1177\/20420986251339580"],"URL":"https:\/\/doi.org\/10.1177\/20420986251339580","relation":{},"ISSN":["2042-0986","2042-0994"],"issn-type":[{"value":"2042-0986","type":"print"},{"value":"2042-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,24]]},"article-number":"20420986251339580"}}